Aysan Erhan, Idiz Ufuk Oguz, Elmas Leyla, Saglam Esra Kaytan, Akgun Zuleyha, Yucel Serap Baskaya
a Department of General Surgery , Bezmialem Vakif University , Istanbul , Turkey.
b Department of General Surgery , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
J Invest Surg. 2017 Jun;30(3):187-192. doi: 10.1080/08941939.2016.1232449. Epub 2016 Oct 4.
This study is aimed to evaluate the effects of boron on radiation-induced skin reactions (RISR) in breast cancer patients.
After 47 patients with invasive ductal carcinoma underwent radiotherapy, 23 (49%) received a boron-based gel, and 24 (51%) received placebo. Assessments were performed according to the Radiation Therapy Oncology Group (RTOG) skin scale and a Five-Point Horizontal Scale (FPHS).
At the end of the fifth week of radiotherapy, the RTOG scores in the boron group were significantly lower than those in the placebo group (p = .024). The FPHS score was higher in the placebo group than in the boron group, and this difference was not statistically significant (p = .079).
Using the RTOG scoring system, we revealed that the application of a boron-based gel diminished RISR. The mechanism of action is unclear but may be related to antioxidant, wound healing, and thermal degradation effects of boron.
本研究旨在评估硼对乳腺癌患者放射性皮肤反应（RISR）的影响。
47例浸润性导管癌患者接受放射治疗后，23例（49%）接受硼基凝胶，24例（51%）接受安慰剂。根据放射治疗肿瘤学组（RTOG）皮肤量表和五点水平量表（FPHS）进行评估。
放疗第5周结束时，硼组的RTOG评分显著低于安慰剂组（p = 0.024）。安慰剂组的FPHS评分高于硼组，且差异无统计学意义（p = 0.079）。
使用RTOG评分系统，我们发现应用硼基凝胶可减轻放射性皮肤反应。其作用机制尚不清楚，但可能与硼的抗氧化、伤口愈合和热降解作用有关。
