[Changes in central hemodynamics and gas exchange after a single and scheduled administration of obsidan in patients with exertion-induced stenocardia and various types of blood circulation].

Sixty-two patients with angina of effort and different circulation types were investigated to assess the pattern of changes in hemodynamics and gas exchange following an acute obsidan test and a course of obsidan treatment. A relationship was demonstrated between the effect of obsidan on central hemodynamics and gas exchange, on the one hand, and the baseline circulatory type, on the other. In patients with hyper- and eukinetic circulation, the drug increased the maximum oxygen uptake and total performance volume in the presence of a variety of hemodynamic changes; such as the negative inotropic and chronotropic effects in the hyperkinetic-type patients, and the negative chronotropic effect in the eukinetic-type ones. In hypokinetic-type patients, the drug had no effect on hemodynamics. The lack of changes in physical working capacity parameters was due to a shift in the conditions of stress exposure towards anaerobic metabolism. A correlation was demonstrated between changes in some hemodynamic and gas exchange parameters following both a single dose and a treatment course of obsidan.