Zdrenghea Mihnea, Sitar-Tăut Adela, Cismaru Gabriel, Zdrenghea Dumitru, Pop Dana
Department of Haematology, Iuliu HaŢieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email:
Department of Cardiology, Iuliu HaŢieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Cardiovasc J Afr. 2017;28(3):201-204. doi: 10.5830/CVJA-2016-068. Epub 2016 Sep 9.
Increased uric acid levels are correlated with cardiovascular disease, particularly with ischaemic heart disease. Xanthine oxidase inhibitors, especially allopurinol, lower the risk of ischaemic heart disease due to their effects on reactive oxygen species and endothelial function. In chronic stable angina pectoris, allopurinol increases the median time to ST depression, time to chest pain, and total exercise time. On the other hand, it has been reported that allopurinol has a beneficial effect on ischaemic patients referred for angioplasty, but there are insufficient data regarding its effect on acute myocardial infarction patients. Moreover, other important actions of allopurinol are regression of left ventricular hypertrophy and improvement in the results of cardiac rehabilitation. The efficacy of allopurinol has recently been acknowledged by the European Society of Cardiology guidelines for stable angina pectoris, but the particular role of allopurinol in ischaemic heart disease patients is not fully established.
尿酸水平升高与心血管疾病相关，尤其是与缺血性心脏病相关。黄嘌呤氧化酶抑制剂，特别是别嘌醇，因其对活性氧和内皮功能的作用而降低缺血性心脏病的风险。在慢性稳定型心绞痛中，别嘌醇可增加ST段压低的中位时间、胸痛发作时间和总运动时间。另一方面，有报道称别嘌醇对接受血管成形术的缺血性患者有有益作用，但关于其对急性心肌梗死患者影响的数据不足。此外，别嘌醇的其他重要作用包括左心室肥厚的消退和心脏康复效果的改善。别嘌醇的疗效最近已得到欧洲心脏病学会稳定型心绞痛指南的认可，但别嘌醇在缺血性心脏病患者中的具体作用尚未完全明确。
