在女性中，尿酸与氧化和炎症呈相反方向的关联。
Uric acid correlates to oxidation and inflammation in opposite directions in women.
作者信息
Wu Sheng Hui, Shu Xiao Ou, Milne Ginger, Xiang Yong-Bing, Zhang Xianglan, Cai Qiuyin, Fazio Sergio, Linton MacRae F, Chen Honglei, Purdue Mark, Rothman Nathaniel, Gao Yu-Tang, Zheng Wei, Yang Gong
机构信息
a Department of Medicine, Division of Epidemiology , Vanderbilt University Medical Center , Nashville , TN , USA .
出版信息
Biomarkers. 2015;20(4):225-31. doi: 10.3109/1354750X.2015.1068852.
Abstract
OBJECTIVE
To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.
METHODS
Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.
RESULTS
Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.
CONCLUSIONS
Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.
摘要
目的
评估尿酸（UA）水平与一组氧化应激和炎症标志物之间的关联。
方法
对755名中国女性测量了血浆UA水平以及一组氧化应激和炎症标志物。
结果
血浆UA水平与氧化应激标志物F2-异前列腺素的尿液水平呈负相关，与血液中的炎症标志物如C反应蛋白和一些促炎细胞因子（肿瘤坏死因子-α和白细胞介素-6）以及尿液中的前列腺素E2代谢产物水平呈正相关。
结论
女性血浆UA水平与氧化和炎症生物标志物呈相反方向的关联。
相似文献
1
Uric acid correlates to oxidation and inflammation in opposite directions in women.
Biomarkers. 2015;20(4):225-31. doi: 10.3109/1354750X.2015.1068852.
2
Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling.
Am J Physiol Regul Integr Comp Physiol. 2014 Jul 1;307(1):R68-74. doi: 10.1152/ajpregu.00092.2014. Epub 2014 Apr 23.
3
Nonexercise physical activity and inflammatory and oxidative stress markers in women.
J Womens Health (Larchmt). 2014 Feb;23(2):159-67. doi: 10.1089/jwh.2013.4456. Epub 2013 Oct 29.
4
Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents.
J Am Diet Assoc. 2009 Mar;109(3):414-21. doi: 10.1016/j.jada.2008.11.036.
5
Longitudinal Impact of Smoking and Smoking Cessation on Inflammatory Markers of Cardiovascular Disease Risk.
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):374-379. doi: 10.1161/ATVBAHA.116.308728. Epub 2016 Dec 8.
6
Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico.
Int J Hyg Environ Health. 2015 Mar;218(2):212-9. doi: 10.1016/j.ijheh.2014.11.001. Epub 2014 Nov 18.
7
Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents.
Obesity (Silver Spring). 2011 Dec;19(12):2404-10. doi: 10.1038/oby.2011.234. Epub 2011 Jul 21.
8
Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women.
J Acad Nutr Diet. 2014 May;114(5):700-8.e2. doi: 10.1016/j.jand.2013.12.019. Epub 2014 Mar 13.
9
Uric Acid Is Associated With Inflammatory Biomarkers and Induces Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells.
Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1241-1249. doi: 10.1161/ATVBAHA.117.309128. Epub 2017 Apr 13.
10
Consumption of high-pressurized vegetable soup increases plasma vitamin C and decreases oxidative stress and inflammatory biomarkers in healthy humans.
J Nutr. 2004 Nov;134(11):3021-5. doi: 10.1093/jn/134.11.3021.
引用本文的文献
1
Metagenomic Insight into Cecal Microbiota Shifts in Broiler Chicks Following spp. Vaccination.
Microorganisms. 2025 Jun 24;13(7):1470. doi: 10.3390/microorganisms13071470.
2
Relationship between serum uric acid and ventricular diastolic dysfunction in type 2 diabetes mellitus patients.
Am J Transl Res. 2025 Mar 15;17(3):2057-2066. doi: 10.62347/CAIV7004. eCollection 2025.
3
Role of uric acid as a biomarker of cognitive function in schizophrenia during maintenance period.
Front Psychiatry. 2023 Mar 22;14:1123127. doi: 10.3389/fpsyt.2023.1123127. eCollection 2023.
4
The Influence of Serum Uric Acid on the Brain and Cognitive Dysfunction.
Front Psychiatry. 2022 Apr 22;13:828476. doi: 10.3389/fpsyt.2022.828476. eCollection 2022.
5
Excess serum uric acid is associated with metabolic syndrome in obese adolescent patients.
J Diabetes Metab Disord. 2020 May 16;19(1):535-543. doi: 10.1007/s40200-020-00507-2. eCollection 2020 Jun.
6
Protective Effects of α-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia.
Curr Med Sci. 2019 Dec;39(6):920-928. doi: 10.1007/s11596-019-2124-1. Epub 2019 Dec 16.
7
Effect of host genotype and Eimeria acervulina infection on the metabolome of meat-type chickens.
PLoS One. 2019 Oct 16;14(10):e0223417. doi: 10.1371/journal.pone.0223417. eCollection 2019.
8
Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications.
Int J Endocrinol. 2018 Nov 29;2018:1765835. doi: 10.1155/2018/1765835. eCollection 2018.
9
The validity, stability, and utility of measuring uric acid in saliva.
Biomark Med. 2018 Jun;12(6):583-596. doi: 10.2217/bmm-2017-0336. Epub 2018 Jun 6.
10
Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins.
Front Endocrinol (Lausanne). 2018 Mar 6;9:75. doi: 10.3389/fendo.2018.00075. eCollection 2018.
本文引用的文献
1
Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women.
Dis Markers. 2013;34(4):279-93. doi: 10.3233/DMA-130969.
2
Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia.
Fundam Clin Pharmacol. 2013 Jun;27(3):252-61. doi: 10.1111/j.1472-8206.2011.01015.x. Epub 2011 Dec 7.
3
Is there anything good in uric acid?
QJM. 2011 Dec;104(12):1015-24. doi: 10.1093/qjmed/hcr159. Epub 2011 Sep 9.
4
Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?
Free Radic Biol Med. 2011 Jun 15;50(12):1787-93. doi: 10.1016/j.freeradbiomed.2011.03.019. Epub 2011 Mar 17.
5
Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men's Health Study.
Nutr Metab Cardiovasc Dis. 2012 May;22(5):409-16. doi: 10.1016/j.numecd.2010.07.012. Epub 2011 Jan 28.
6
Obesity, age, and oxidative stress in middle-aged and older women.
Antioxid Redox Signal. 2011 Jun 15;14(12):2453-60. doi: 10.1089/ars.2010.3337. Epub 2011 Mar 21.
7
Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo.
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14351-6. doi: 10.1073/pnas.1001072107. Epub 2010 Jul 26.
8
Uric acid promotes an acute inflammatory response to sterile cell death in mice.
J Clin Invest. 2010 Jun;120(6):1939-49. doi: 10.1172/JCI40124. Epub 2010 May 24.
9
Intra-person variation of urinary biomarkers of oxidative stress and inflammation.
Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):947-52. doi: 10.1158/1055-9965.EPI-10-0046. Epub 2010 Mar 23.
10
Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study.
Atherosclerosis. 2010 Mar;209(1):215-9. doi: 10.1016/j.atherosclerosis.2009.08.012. Epub 2009 Aug 14.
Zotero 插件