Berstein L M, Kovaleva I G, Pravosudov I V, Dilman V M
Prof. N. N. Petrov Research Institute of Oncology, Ministry of Health, Leningrad, USSR.
Neoplasma. 1989;36(4):465-71.
Peculiarities in hormonal regulation of adenylate cyclase (AC) were studied in large bowel tumors to establish criteria of their hormonal dependence. The investigation showed a diminished basal activity of AC matched by decreased response to sodium fluoride, glucagon, and vasoactive intestinal peptide (VIP) in tumors as compared with normal intestinal mucosa. Some cases revealed an increased response of AC to a nonspecific ("inappropriate") stimulator--calcitonin. This was rather typical of colonic tumors while a diminished response to specific ("appropriate") stimulation by VIP and glucagon was more frequent in rectal cancer. The results showed a relationship between hormonal regulation of AC activity and lipid composition of tumor tissue, thus suggesting the possibility of influencing the hormone dependence of intestinal tumors by drugs used to eliminate disturbance of fat-carbohydrate metabolism.
为确定大肠肿瘤激素依赖性的标准，对腺苷酸环化酶（AC）的激素调节特性进行了研究。研究表明，与正常肠黏膜相比，肿瘤中AC的基础活性降低，对氟化钠、胰高血糖素和血管活性肠肽（VIP）的反应也降低。一些病例显示AC对非特异性（“不适当”）刺激物——降钙素的反应增加。这在结肠肿瘤中相当典型，而直肠癌中对VIP和胰高血糖素的特异性（“适当”）刺激反应降低更为常见。结果表明AC活性的激素调节与肿瘤组织的脂质组成之间存在关联，从而提示可通过用于消除脂肪-碳水化合物代谢紊乱的药物来影响肠道肿瘤的激素依赖性。
