Bershteĭn L M, Kovaleva I G, Pravosudov I V
Vopr Med Khim. 1988 May-Jun;34(3):71-4.
Hormonal regulation of the adenylate cyclase activity was studied in tumors of rectum and colon. A relative increase in sensitivity of the enzyme to inappropriate stimulators (especially to calcitonin) and lowering of the adenylate cyclase response in presence of more specific effectors (glucagon) were observed in 35-40% cases of these tumors. The positive correlation was found between the frequency of adenylate cyclase response and the content of cholesterol and its fractions in the tumor tissues. Possible hormone-dependent mechanisms in the tumor tissues are discussed.
对直肠和结肠肿瘤中腺苷酸环化酶活性的激素调节进行了研究。在这些肿瘤的35%至40%的病例中，观察到该酶对不适当刺激物（尤其是降钙素）的敏感性相对增加，以及在存在更特异性效应物（胰高血糖素）时腺苷酸环化酶反应降低。发现肿瘤组织中腺苷酸环化酶反应频率与胆固醇及其组分含量之间存在正相关。讨论了肿瘤组织中可能的激素依赖性机制。
