Javadi Fatemeh, Ahmadzadeh Arman, Eghtesadi Shahryar, Aryaeian Naheed, Zabihiyeganeh Mozhdeh, Rahimi Foroushani Abbas, Jazayeri Shima
a Department of Clinical Nutrition , School of Nutritional Sciences & Dietetics, Tehran University of Medical Sciences , Tehran , IRAN.
e Department of Rheumatology , Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences , Tehran , IRAN.
J Am Coll Nutr. 2017 Jan;36(1):9-15. doi: 10.1080/07315724.2016.1140093. Epub 2016 Oct 6.
Previous studies have shown that the bioflavonoid quercetin has anti-inflammatory and anti-nociceptive effects. We investigated the effect of quercetin supplementation on inflammation, disease severity, and clinical symptoms in women with rheumatoid arthritis (RA).
The present study was a randomized, double-blind, placebo-controlled clinical trial in which 50 women with RA were allocated into a quercetin (500 mg/day) or placebo group for 8 weeks. Plasma levels of high-sensitivity tumor necrosis factor-α (hs-TNFα), erythrocyte sedimentation rate (ESR), clinical symptoms including early morning stiffness (EMS), morning and after-activity pain, and tender (TSC) and swollen joint counts (SJC) were determined. Disease activity and functional disability were assessed by Disease Activity Score 28 (DAS-28), physician global assessment (PGA), and a health assessment questionnaire (HAQ) at the beginning and end of the study.
Quercetin supplementation for 8 weeks significantly reduced EMS, morning pain, and after-activity pain (p < 0.05). DAS-28 and HAQ scores decreased in the quercetin group compared to placebo and the number of patients with active disease significantly decreased in the quercetin group. Plasma hs-TNFα level was significantly reduced in the quercetin group compared to placebo (p < 0.05). There were no significant differences in TJC and SJC between groups but TJC significantly decreased in the quercetin group after the intervention. Supplementation had an effect on ESR but it was not significant (p > 0.05).
Five hundred milligrams per day quercetin supplementation for 8 weeks resulted in significant improvements in clinical symptoms, disease activity, hs-TNFα, and HAQ in women with RA.
先前的研究表明，生物类黄酮槲皮素具有抗炎和抗伤害感受作用。我们研究了补充槲皮素对类风湿关节炎（RA）女性患者炎症、疾病严重程度及临床症状的影响。
本研究为一项随机、双盲、安慰剂对照临床试验，将50名RA女性患者分为槲皮素组（500毫克/天）或安慰剂组，为期8周。测定血浆高敏肿瘤坏死因子-α（hs-TNFα）水平、红细胞沉降率（ESR），以及包括晨僵（EMS）、活动前后疼痛、压痛关节计数（TSC）和肿胀关节计数（SJC）在内的临床症状。在研究开始和结束时，通过疾病活动评分28（DAS-28）、医生整体评估（PGA）和健康评估问卷（HAQ）评估疾病活动度和功能残疾情况。
补充槲皮素8周可显著减轻EMS、活动前疼痛和活动后疼痛（p<0.05）。与安慰剂组相比，槲皮素组的DAS-28和HAQ评分降低，且槲皮素组活动性疾病患者数量显著减少。与安慰剂组相比，槲皮素组血浆hs-TNFα水平显著降低（p<0.05）。两组间TSC和SJC无显著差异，但干预后槲皮素组TSC显著降低。补充槲皮素对ESR有影响，但不显著（p>0.05）。
每天补充500毫克槲皮素，持续8周，可使RA女性患者的临床症状、疾病活动度、hs-TNFα水平和HAQ得到显著改善。
