Mandalari Giuseppina, Chessa Simona, Bisignano Carlo, Chan Luisa, Carughi Arianna
IFR-Extra, Institute of Food Research, Norwich Research Park, Colney Lane, NR4 7UA, Norwich, UK and Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Salita Sperone 31, 98168 Messina, Italy.
The Model Gut, Institute of Food Research, Norwich Research Park, Colney Lane, NR4 7UA, Norwich, UK.
Food Funct. 2016 Sep 14;7(9):4048-4060. doi: 10.1039/c6fo01137c.
Modulation of the human gut microbiota has proven to have beneficial effects on host health. The aim of this work was to evaluate the effect of sun-dried raisins (SR) on the composition of the human gut microbiota. A full model of the gastrointestinal tract, which includes simulated mastication, a dynamic gastric model, a duodenal model and a colonic model of the human large intestine, was used. An increase in the numbers of bifidobacteria and lactobacilli was observed by plate-counting in response to the addition of either SR or FOS after 8 and 24 h fermentation. A significant decrease in Firmicutes and Bacteroidetes was observed in SR samples after 8 and 24 h fermentation. FOS resulted in the greatest production of short chain fatty acids. Sun-dried raisins demonstrated considerable potential to promote the colonization and proliferation of beneficial bacteria in the human large intestine and to stimulate the production of organic acids.
已证明调节人类肠道微生物群对宿主健康具有有益影响。这项工作的目的是评估葡萄干（SR）对人类肠道微生物群组成的影响。使用了一个胃肠道的完整模型，该模型包括模拟咀嚼、动态胃模型、十二指肠模型和人类大肠的结肠模型。在8小时和24小时发酵后，通过平板计数观察到，添加SR或低聚果糖（FOS）后双歧杆菌和乳酸杆菌数量增加。在8小时和24小时发酵后，SR样品中厚壁菌门和拟杆菌门的数量显著减少。FOS产生的短链脂肪酸最多。葡萄干显示出在人类大肠中促进有益细菌定殖和增殖以及刺激有机酸产生的巨大潜力。
