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1
Some factors affecting the specific toxicity of misonidazole towards hypoxic mammalian cells.一些影响米索硝唑对缺氧哺乳动物细胞特异性毒性的因素。
Br J Cancer Suppl. 1978 Jun;3:129-31.
2
Misonidazole and MTDQ in combination: cytotoxic and radiosensitizing properties in hypoxic mammalian cells.米索硝唑与MTDQ联合应用：对缺氧哺乳动物细胞的细胞毒性和放射增敏特性
Br J Cancer. 1979 May;39(5):510-5. doi: 10.1038/bjc.1979.94.
3
Increased radiosensitivity of aerobic mammalian cells following pre-incubation with misonidazole in hypoxia.
Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1271-4. doi: 10.1016/0360-3016(84)90331-6.
4
The effect of misonidazole as a hypoxic radiosensitizer at low dose.低剂量米索硝唑作为低氧放射增敏剂的作用。
Radiat Res. 1984 Nov;100(2):340-7.
5
Cytotoxic properties of a 4-nitroimidazole (NSC 38087): a radiosensitizer of hypoxic cells in vitro.一种4-硝基咪唑（NSC 38087）的细胞毒性特性：体外缺氧细胞的放射增敏剂。
Br J Cancer. 1981 Jul;44(1):109-16. doi: 10.1038/bjc.1981.155.
6
Sensitizing and toxicity properties of misonidazole and its derivatives.米索硝唑及其衍生物的致敏性和毒性特性。
Br J Cancer Suppl. 1978 Jun;3:115-9.
7
[Toxic and radiosensitizing effect of reduced nitroimidazoles on E. coli B/r cells].[还原型硝基咪唑对大肠杆菌B/r细胞的毒性及放射增敏作用]
Radiobiologiia. 1983 Jul-Aug;23(4):505-9.
8
Radiosensitization of mammalian cells by misonidazole and oxygen: DNA damage exposed by Micrococcus luteus enzymes.米索硝唑和氧气对哺乳动物细胞的放射增敏作用：藤黄微球菌酶揭示的DNA损伤
Radiat Res. 1979 Sep;79(3):591-600.
9
The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.灭滴灵与辐射、化疗药物或热的相互作用：初步报告。
Cancer Clin Trials. 1980 Fall;3(3):231-6.
10
Effect of hypoxia on the cytotoxicity of misonidazole in HELA S3 cells in vitro.
Gan. 1980 Jun;71(3):319-24.

引用本文的文献

1
Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro.巯基、抗坏血酸盐和氧作为米索硝唑体外毒性和代谢的调节剂。
Br J Cancer. 1980 Jun;41(6):892-900. doi: 10.1038/bjc.1980.166.
2
Mitochondrial alterations produced by misonidazole: a study using Amoeba proteus as a single-cell model.米索硝唑引起的线粒体改变：以大变形虫为单细胞模型的研究
Br J Cancer. 1980 Feb;41(2):305-8. doi: 10.1038/bjc.1980.44.
3
Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron-affinity relationship.适度热疗增强放射增敏剂的细胞毒性：电子亲和力关系
Br J Cancer. 1982 Dec;46(6):912-7. doi: 10.1038/bjc.1982.301.
4
Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air.米索硝唑对缺氧细胞进行预处理增强其在空气中对美法仑反应的作用。
Br J Cancer. 1982 Jul;46(1):117-26. doi: 10.1038/bjc.1982.173.
5
Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.低浓度的米索硝唑可抵消极端缺氧对S期细胞的影响。
Br J Cancer. 1981 Mar;43(3):355-66. doi: 10.1038/bjc.1981.56.
6
Split dose cytotoxic experiments with misonidazole.米索硝唑的分剂量细胞毒性实验。
Br J Cancer. 1978 Jul;38(1):130-6. doi: 10.1038/bjc.1978.172.
7
Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions.在缺氧和无氧条件下，抗坏血酸阴离子可增强硝基芳香化合物的细胞毒性。
Br J Cancer. 1979 Mar;39(3):321-9. doi: 10.1038/bjc.1979.56.

本文引用的文献

1
Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.亲电子致敏作用。V. 某些硝基咪唑和硝基吡唑对缺氧细菌和哺乳动物细胞的体外放射致敏作用
Radiat Res. 1974 Oct;60(1):108-18.
2
Increased sensitivity of mammalian cell cultures to radiomimetic alkylating agents following incorporation of 5-bromodeoxyuridine into cellular DNA.将5-溴脱氧尿苷掺入细胞DNA后，哺乳动物细胞培养物对拟放射性烷化剂的敏感性增加。
Biochem Pharmacol. 1966 Dec;15(12):2013-23. doi: 10.1016/0006-2952(66)90229-2.
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Sensitization of anoxic mammalian cells to x-rays by triacetoneamine N-oxyl. Survival and toxicity studies.
Radiat Res. 1969 Jun;38(3):493-500.
4
Survival response of asynchronous and synchronous Chinese hamster cells exposed to fluorescent light following 5-bromodeoxyuridine incorporation.在掺入5-溴脱氧尿苷后，异步和同步中国仓鼠细胞对荧光照射的存活反应。
Mutat Res. 1972 Feb;14(2):237-45. doi: 10.1016/0027-5107(72)90050-4.
5
Hypoxic sensitizers: radiobiological studies at the cellular level.缺氧敏化剂：细胞水平的放射生物学研究
Radiology. 1975 Nov;117(2):453-7. doi: 10.1148/117.2.453.
6
Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.两种硝基咪唑类放射增敏剂在体外肿瘤模型中的细胞毒性
Int J Radiat Oncol Biol Phys. 1976 Nov-Dec;1(11-12):1149-57. doi: 10.1016/0360-3016(76)90088-2.
7
Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.2-硝基咪唑Ro-07-0582对缺氧哺乳动物细胞的放射增敏及毒性作用。
Radiat Res. 1976 Sep;67(3):459-73.
8
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.Ro-07-0582的细胞毒性；热疗增强作用及半胱胺的保护作用
Br J Cancer. 1977 Jun;35(6):809-15. doi: 10.1038/bjc.1977.122.
9
Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.热疗对缺氧细胞放射增敏剂Ro-07-0582体外对哺乳动物细胞的差异细胞毒性的影响。
Br J Cancer. 1977 Mar;35(3):307-13. doi: 10.1038/bjc.1977.44.

一些影响米索硝唑对缺氧哺乳动物细胞特异性毒性的因素。

Some factors affecting the specific toxicity of misonidazole towards hypoxic mammalian cells.

作者信息

Stratford I J, Gray P

出版信息

Br J Cancer Suppl. 1978 Jun;3:129-31.

PMID:277212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149360/
Abstract

The toxic action of misonidazole towards hypoxic mammalian cells has been shown to be a function of serum concentration, with higher serum concentrations enhancing the toxic effect. Added thiols protect cells against misonidazole toxicity. In addition, the action of misonidazole on hypoxic cells labelled with 5-BUdR has been examined. Cells with incroported 5-BUdR are no more sensitive to misonidazole toxicity than are cells without label.

摘要

已证明米索硝唑对缺氧哺乳动物细胞的毒性作用是血清浓度的函数，血清浓度越高，毒性作用越强。添加的硫醇可保护细胞免受米索硝唑的毒性作用。此外，还研究了米索硝唑对用5-溴脱氧尿苷（5-BUdR）标记的缺氧细胞的作用。摄取了5-BUdR的细胞对米索硝唑毒性的敏感性并不比未标记的细胞更高。