一些影响米索硝唑对缺氧哺乳动物细胞特异性毒性的因素。
Some factors affecting the specific toxicity of misonidazole towards hypoxic mammalian cells.
作者信息
Stratford I J, Gray P
出版信息
Br J Cancer Suppl. 1978 Jun;3:129-31.
Abstract
The toxic action of misonidazole towards hypoxic mammalian cells has been shown to be a function of serum concentration, with higher serum concentrations enhancing the toxic effect. Added thiols protect cells against misonidazole toxicity. In addition, the action of misonidazole on hypoxic cells labelled with 5-BUdR has been examined. Cells with incroported 5-BUdR are no more sensitive to misonidazole toxicity than are cells without label.
摘要
已证明米索硝唑对缺氧哺乳动物细胞的毒性作用是血清浓度的函数，血清浓度越高，毒性作用越强。添加的硫醇可保护细胞免受米索硝唑的毒性作用。此外，还研究了米索硝唑对用5-溴脱氧尿苷（5-BUdR）标记的缺氧细胞的作用。摄取了5-BUdR的细胞对米索硝唑毒性的敏感性并不比未标记的细胞更高。
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