放射增敏剂在多细胞球体中的细胞毒性：与热疗的联合治疗
Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.
作者信息
Sutherland R, Macfarlane W
出版信息
Br J Cancer Suppl. 1978 Jun;3:168-72.
Abstract
Spheroids of EMT6 tumour cells were grown in spinner culture. As with V79 cell spheroids, the combination of 1.5mM misonidazole and hyperthermia at 42.5 degree C for 1 or 2 h cuased greater cytotoxicity than either heat or drug alone. Radioresistant hypoxic cells at the centre of the spheroids were eliminated but other cells were also killed.
摘要
EMT6肿瘤细胞球体在旋转培养中生长。与V79细胞球体一样，1.5mM米索硝唑与42.5摄氏度的热疗联合作用1或2小时，比单独使用热疗或药物产生更大的细胞毒性。球体中心的耐辐射缺氧细胞被消除，但其他细胞也被杀死。
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本文引用的文献
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Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration.信函：通过控制细胞呼吸对体外肿瘤模型辐射反应的修饰
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Dec;26(6):597-601. doi: 10.1080/09553007414551641.
2
Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model.在体外肿瘤模型中，硝呋肟对缺氧细胞的放射增敏作用。
Int J Radiat Biol Relat Stud Phys Chem Med. 1972 Dec;22(6):613-8. doi: 10.1080/09553007214551511.
3
Selective chemotherapy of noncycling cells in an in vitro tumor model.体外肿瘤模型中非循环细胞的选择性化疗。
Cancer Res. 1974 Dec;34(12):3501-3.
4
5
Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells.甲硝唑（灭滴灵）：作为一种对缺氧肿瘤细胞具有特异性的细胞毒性药物的特性
Br J Cancer. 1976 May;33(5):485-90. doi: 10.1038/bjc.1976.78.
6
7
8
Letter: Enhanced killing of hypoxic tumour cells by hyperthemia.信件：热疗增强对缺氧肿瘤细胞的杀伤作用。
Br J Radiol. 1975 Oct;48(574):872-4. doi: 10.1259/0007-1285-48-574-872-c.
9
Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.两种硝基咪唑类放射增敏剂在体外肿瘤模型中的细胞毒性
Int J Radiat Oncol Biol Phys. 1976 Nov-Dec;1(11-12):1149-57. doi: 10.1016/0360-3016(76)90088-2.
10
Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.2-硝基咪唑Ro-07-0582对缺氧哺乳动物细胞的放射增敏及毒性作用。
Radiat Res. 1976 Sep;67(3):459-73.
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