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放射增敏剂在多细胞球体中的细胞毒性：与热疗的联合治疗

Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.

作者信息

Sutherland R, Macfarlane W

出版信息

Br J Cancer Suppl. 1978 Jun;3:168-72.

PMID:277220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149386/
Abstract

Spheroids of EMT6 tumour cells were grown in spinner culture. As with V79 cell spheroids, the combination of 1.5mM misonidazole and hyperthermia at 42.5 degree C for 1 or 2 h cuased greater cytotoxicity than either heat or drug alone. Radioresistant hypoxic cells at the centre of the spheroids were eliminated but other cells were also killed.

摘要

EMT6肿瘤细胞球体在旋转培养中生长。与V79细胞球体一样，1.5mM米索硝唑与42.5摄氏度的热疗联合作用1或2小时，比单独使用热疗或药物产生更大的细胞毒性。球体中心的耐辐射缺氧细胞被消除，但其他细胞也被杀死。

相似文献

1
Cytotoxicity of radiosensitizers in multicell spheroids: combination treatment with hyperthermia.放射增敏剂在多细胞球体中的细胞毒性：与热疗的联合治疗
Br J Cancer Suppl. 1978 Jun;3:168-72.
2
An in vitro and in vivo screening system for new hypoxic cell radiosensitizers using EMT6 cells.一种使用EMT6细胞的新型乏氧细胞放射增敏剂的体外和体内筛选系统。
Jpn J Cancer Res. 1986 Oct;77(10):1027-33.
3
The response of EMT6 tumor spheroids to combined treatment with misonidazole and either nitrogen mustard, adriamycin, or BCNU.EMT6肿瘤球体对米索硝唑与氮芥、阿霉素或卡氮芥联合治疗的反应。
Cancer Clin Trials. 1980 Fall;3(3):253-6.
4
Interactions between misonidazole and hyperthermia in EMT6 spheroids.米索硝唑与热疗在EMT6球体中的相互作用。
Br J Cancer. 1981 Dec;44(6):810-8. doi: 10.1038/bjc.1981.279.
5
Cytotoxicity of hypoxic cell sensitizers in multicell spheroids.缺氧细胞增敏剂在多细胞球体中的细胞毒性。
Cancer Clin Trials. 1980 Spring;3(1):73-83.
6
Enhancement of local tumour control by misonidazole and hyperthermia.甲硝唑与热疗联合增强局部肿瘤控制效果
Br J Cancer Suppl. 1978 Jun;3:178-83.
7
Cytotoxic and radiosensitizing effects of hypoxic cell sensitizers on EMT6 mouse mammary tumour cells in vivo and in vitro.乏氧细胞增敏剂对EMT6小鼠乳腺肿瘤细胞的体内外细胞毒性及放射增敏作用
Br J Cancer Suppl. 1978 Jun;3:212-5.
8
The demonstration of in vivo misonidazole tumour toxicity using post radiation hypoxia.利用放疗后缺氧情况对米索硝唑的体内肿瘤毒性进行的论证。
Br J Cancer Suppl. 1978 Jun;3:228-31.
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Radiation response of multicell spheroids--an in vitro tumour model.多细胞球体的辐射反应——一种体外肿瘤模型
Curr Top Radiat Res Q. 1976 Jan;11(1):87-139.
10
The nitroimidazoles as radiosensitizers and cytotoxic agents.作为放射增敏剂和细胞毒剂的硝基咪唑类药物。
Br J Cancer Suppl. 1978 Jun;3:120-3.

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Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids.三维神经母细胞瘤细胞培养：单层细胞与多细胞肿瘤球体之间的蛋白质组学分析
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Multicellular spheroids. A review on cellular aggregates in cancer research.多细胞球体。癌症研究中细胞聚集体的综述。
J Cancer Res Clin Oncol. 1987;113(2):101-22. doi: 10.1007/BF00391431.

本文引用的文献

1
Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration.信函：通过控制细胞呼吸对体外肿瘤模型辐射反应的修饰
Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Dec;26(6):597-601. doi: 10.1080/09553007414551641.
2
Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model.在体外肿瘤模型中，硝呋肟对缺氧细胞的放射增敏作用。
Int J Radiat Biol Relat Stud Phys Chem Med. 1972 Dec;22(6):613-8. doi: 10.1080/09553007214551511.
3
Selective chemotherapy of noncycling cells in an in vitro tumor model.体外肿瘤模型中非循环细胞的选择性化疗。
Cancer Res. 1974 Dec;34(12):3501-3.
4
Metabolic aspects of the role of hyperthermia im mammalian cell inactivation and their possible relevance to cancer treatment.热疗在哺乳动物细胞失活中的作用的代谢方面及其与癌症治疗的可能相关性。
Cancer Res. 1974 Nov;34(11):3117-23.
5
Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells.甲硝唑（灭滴灵）：作为一种对缺氧肿瘤细胞具有特异性的细胞毒性药物的特性
Br J Cancer. 1976 May;33(5):485-90. doi: 10.1038/bjc.1976.78.
6
The effects of nitrobenzene derivatives on oxygen utilization and radiation response of an in vitro tumor model.硝基苯衍生物对体外肿瘤模型氧利用和辐射反应的影响。
Radiat Res. 1976 Mar;65(3):529-39.
7
Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.与需氧哺乳动物细胞相比，甲硝唑和呋喃西林对缺氧哺乳动物细胞的杀伤作用增强。
Cancer Res. 1976 Mar;36(3):930-6.
8
Letter: Enhanced killing of hypoxic tumour cells by hyperthemia.信件：热疗增强对缺氧肿瘤细胞的杀伤作用。
Br J Radiol. 1975 Oct;48(574):872-4. doi: 10.1259/0007-1285-48-574-872-c.
9
Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.两种硝基咪唑类放射增敏剂在体外肿瘤模型中的细胞毒性
Int J Radiat Oncol Biol Phys. 1976 Nov-Dec;1(11-12):1149-57. doi: 10.1016/0360-3016(76)90088-2.
10
Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.2-硝基咪唑Ro-07-0582对缺氧哺乳动物细胞的放射增敏及毒性作用。
Radiat Res. 1976 Sep;67(3):459-73.