Von Burg R, Conroy P J, Passalacqua W
Br J Cancer. 1979 Jul;40(1):134-43. doi: 10.1038/bjc.1979.149.
The clinical use of the radiosensitizer misonidazole may be limited by the incidence of peripheral neuropathy reported following total doses in excess of 18 g. A recent report noted a decrease in nerve conduction velocity following a single i.p. injection of 1 mg/g misonidazole in mice. The present study was unable to confirm such changes when nerve conduction velocity measurements were made in situ or in isolated sural, tibial or median nerves of mice. Other electrophysiological parameters such as threshold, strength-duration curves, refractory time or the ability to carry high-frequency stimulation also showed no change. However, it was noted that a single administration of the radio-sensitizer produced a marked decrease in body temperature which persisted for at least 2 h after the elimination of the drug from the blood serum. The physiological response of reduction of body temperature may protect the mouse against the effect of the toxic chemical species involved in the induction of neurotoxicity.
放射增敏剂米索硝唑的临床应用可能会受到外周神经病变发生率的限制，据报道，总剂量超过18克后会出现这种情况。最近一份报告指出，小鼠腹腔注射1毫克/克米索硝唑后神经传导速度下降。在本研究中，当在小鼠原位或分离的腓肠神经、胫神经或正中神经中测量神经传导速度时，无法证实这种变化。其他电生理参数，如阈值、强度-时间曲线、不应期或携带高频刺激的能力也没有变化。然而，值得注意的是，单次给予放射增敏剂会导致体温显著下降，在血清中药物消除后，这种下降至少持续2小时。体温降低的生理反应可能会保护小鼠免受参与诱导神经毒性的有毒化学物质的影响。
