缺氧细胞敏化剂对肿瘤生长延迟和细胞存活的影响。对原位和体外细胞存活的意义。
The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro.
作者信息
McNally N J
出版信息
Br J Cancer. 1975 Nov;32(5):610-8. doi: 10.1038/bjc.1975.268.
Abstract
A comparison has been made of the effects of the 2-nitroimidazole Ro-07-0582 on tumour growth delay after irradiation and tumour cell survival in vitro after irradiation in vivo. This compound has previously been shown to be a specific sensitizer of hypoxic cells. A dose of 1 mg/g body weight gave an enhancement ratio of 2-2 for both growth delay and cell survival in a system where high pressure oxygen has been shown to have no effect. However, while the hypoxic fraction in the tumour was estimated to be less then 10% from the growth delay curves, the survival curves gave a value in excess of 50%. This discrepancy probably reflects differences in the response of cells left in situ or removed and assayed in vitro.
摘要
对2-硝基咪唑Ro-07-0582在体内照射后对肿瘤生长延迟的影响以及体内照射后体外肿瘤细胞存活情况进行了比较。该化合物先前已被证明是缺氧细胞的特异性增敏剂。在高压氧已被证明无作用的系统中，1mg/g体重的剂量对生长延迟和细胞存活的增强比均为2.2。然而，虽然根据生长延迟曲线估计肿瘤中的缺氧部分小于10%，但存活曲线给出的值超过50%。这种差异可能反映了原位留存细胞或取出并在体外检测的细胞反应的差异。
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本文引用的文献
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Ann N Y Acad Sci. 1961 Nov 13;95:818-27. doi: 10.1111/j.1749-6632.1961.tb50078.x.
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The gross response of an experimental tumour to single doses of x-rays.实验性肿瘤对单次X射线剂量的总体反应。
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Growth rate and radiosensitivity of human tumours. I. Growth rate of human tumours.人类肿瘤的生长速率与放射敏感性。I. 人类肿瘤的生长速率
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The effect on cell survival of inhalation of oxygen under high pressure during irradiation in vivo of a solid mouse sarcoma.在对实体小鼠肉瘤进行体内照射期间高压吸入氧气对细胞存活的影响。
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Radiation effects on death and migration of tumor cells in mice.辐射对小鼠肿瘤细胞死亡和迁移的影响。
Radiat Res. 1970 Sep;43(3):663-78.
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A comparison of the effects of radiation on tumour growth delay and cell survival. The effect of oxygen.辐射对肿瘤生长延迟和细胞存活影响的比较。氧气的作用。
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