米索硝唑对人胰腺癌克隆形成细胞辐射反应的影响。
The effect of misonidazole on the radiation response of clonogenic human pancreatic carcinoma cells.
作者信息
Courtenay V D, Smith I E, Steel G G
出版信息
Br J Cancer Suppl. 1978 Jun;3:225-7.
An enhancing effect of misonidazole on the in vivo radiation response of clonogenic human tumour cells from a pancreatic carcinoma xenograft has been demonstrated using both a soft agar in vitro assay and an agar in diffusion chamber assay. Enhancement ratios of 1.8 and 1.3 were found when cells were assayed at 0 h and 18 h respectively after irradiation. No enhancement was seen with in vitro irradiation of oxygenated cells. The potential of these assay systems as a perclinical screening test for new radiosensitizers is discussed.
使用软琼脂体外测定法和扩散室琼脂测定法，已证明米索硝唑对源自胰腺癌异种移植瘤的克隆形成性人肿瘤细胞的体内辐射反应具有增强作用。在照射后分别于0小时和18小时对细胞进行测定时，增强比分别为1.8和1.3。对含氧细胞进行体外照射时未观察到增强作用。讨论了这些测定系统作为新放射增敏剂临床前筛选试验的潜力。
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