Wrzesień Małgorzata
Faculty of Physics and Applied Informatics, Department of Nuclear Physics and Radiation Safety, University of Lodz, Pomorska 149/153, 90-236, Lodz, Poland.
Australas Phys Eng Sci Med. 2018 Jun;41(2):541-548. doi: 10.1007/s13246-018-0644-9. Epub 2018 May 7.
The production of the F isotope-the marker of deoxyglucose (F-FDG)-the radiopharmaceutical most commonly used in the oncological diagnostic technique of positron emission tomography, requires a cyclotron device. At present, there are nine facilities working in Poland that are equipped with cyclotrons used for producing the short-lived isotopes. The aim of the paper is to determine the hand exposure of workers employed in the two F-FDG production centres taking in to account the production procedures and work system in those facilities. Measurements, which included all professional workers exposed to ionizing radiation that were employed in two facilities, were performed by using high-sensitivity thermoluminescent detectors during the routine activities of the personnel. The work system used at the production centre has an impact on the level of the recorded doses. Among the production procedures performed by the staff, the highest ionizing radiation doses have been received by the staff during the F-FDG quality control. The maximum estimated annual Hp(0.07) for chemists from the quality control department can exceed the annual skin limit dose (500 mSv). The source of lowest doses on the hands are the cyclotron operating procedure and the F-FDG production, provided that these procedures can't be combined with other production procedures.
氟同位素（脱氧葡萄糖的标记物——氟代脱氧葡萄糖，即F-FDG）的生产需要一台回旋加速器装置，而F-FDG是正电子发射断层扫描肿瘤诊断技术中最常用的放射性药物。目前，波兰有9个配备回旋加速器的设施用于生产短寿命同位素。本文旨在考虑这些设施的生产程序和工作系统，确定两个F-FDG生产中心员工的手部受照情况。测量由两个设施中所有暴露于电离辐射的专业工作人员完成，在人员日常活动期间使用高灵敏度热释光探测器进行测量。生产中心所采用的工作系统对记录的剂量水平有影响。在工作人员执行的生产程序中，F-FDG质量控制期间工作人员接受的电离辐射剂量最高。质量控制部门化学人员的最大估计年Hp(0.07)剂量可能超过年皮肤剂量限值（500毫希沃特）。手部剂量最低的来源是回旋加速器操作程序和F-FDG生产，前提是这些程序不能与其他生产程序合并。
