顺二氯二氨铂（II）作为放射增敏剂的研究。

Studies on cis-dichlorodiammineplatinum (II) as a radiosensitizer.

作者信息

Alvarez M V, Cobreros G, Heras A, Lopez Zumel M C

出版信息

Br J Cancer Suppl. 1978 Jun;3:68-72.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149413/

Abstract

Cis-dichlorodiammineplatinum (II) (cisDDP) has been extensively studied as an antitumour agent; its binding to DNA has been proved but the radiosensitizing action has scarcely been tested. We report here that on TC.SV -40 mammalian cells cisDPP acts as a dose-modifying factor for ionizing radiation. The radiosensitizing action can be induced by two different mechanisms: reaction with non protein-SH groups and inhibition of repair processes. The cisDDP-DNA complex was studied against increasing radiation doses by analytical centrifugation and by spectrophotometrical measurements. The native complex seems to be more radiation resistant than the denatured one.

摘要

顺式二氯二氨合铂（II）（顺铂）作为一种抗肿瘤药物已得到广泛研究；其与DNA的结合已得到证实，但放射增敏作用几乎未被测试。我们在此报告，顺铂对TC.SV -40哺乳动物细胞起到电离辐射剂量修饰因子的作用。放射增敏作用可通过两种不同机制诱导产生：与非蛋白质巯基反应以及抑制修复过程。通过分析离心和分光光度测量，研究了顺铂 - DNA复合物对不断增加的辐射剂量的反应。天然复合物似乎比变性复合物更耐辐射。

相似文献

1

Studies on cis-dichlorodiammineplatinum (II) as a radiosensitizer.顺二氯二氨铂（II）作为放射增敏剂的研究。

Br J Cancer Suppl. 1978 Jun;3:68-72.

2

[Platinum complexes as radiosensitizers in radiotherapy].

Rev Esp Oncol. 1984;31(2):227-36.

3

Oxygen- and temperature-dependent cytotoxic and radiosensitizing effects of cis-dichlorodiammineplatinum(II) on human NHIK 3025 cells in vitro.顺二氯二氨铂（II）对人NHIK 3025细胞的氧和温度依赖性细胞毒性及放射增敏作用的体外研究

Radiat Res. 1988 Jun;114(3):489-99.

4

Platinum complexes as radiosensitizers of hypoxic mammalian cells.铂配合物作为缺氧哺乳动物细胞的放射增敏剂。

Br J Cancer Suppl. 1978 Jun;3:98-102.

5

Radiation-induced DNA damage and lethality in E. coli as modified by the antitumor agent cis-dichlorodiammineplatinum (II).

Radiat Res. 1977 Aug;71(2):447-60.

6

Toxic variability and radiation sensitization by dichlorodiammineplatinum(II) complexes in Salmonella typhimurium cells.二氯二氨铂（II）配合物对鼠伤寒沙门氏菌细胞的毒性变异性和辐射增敏作用

Radiat Res. 1984 Sep;99(3):596-608.

7

Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells.拓扑异构酶II抑制作用以及在人胶质母细胞瘤细胞中，亚硝基脲和顺铂诱导的DNA链间交联的形成与修复动力学改变和细胞毒性

Cancer Res. 1993 Dec 1;53(23):5663-8.

8

Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II).顺二氨二氯铂（II）处理的对照及突变人类细胞中DNA链间交联的形成与修复及其与细胞毒性和DNA非预定合成的关系

Cancer Res. 1985 Sep;45(9):4178-84.

9

Resistance patterns between cis-diamminedichloroplatinum(II) and ionizing radiation.

Cancer Res. 1991 Sep 1;51(17):4523-7.

10

Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum.顺二氯二氨合铂（II）对六种哺乳动物细胞系的细胞杀伤作用与顺二氯二氨合铂（II）-DNA抗血清结合之间的相关性。

Cancer Res. 1990 Jun 15;50(12):3556-61.

引用本文的文献

1

Intra-arterial Chemotherapy for Head and Neck Cancer.头颈部癌的动脉内化疗

Interv Radiol (Higashimatsuyama). 2023 Jun 3;9(3):127-133. doi: 10.22575/interventionalradiology.2022-0042. eCollection 2024 Nov 1.

2

Impact of fractionated cisplatin and radiation treatment on cell growth and accumulation of DNA damage in two normal cell types differing in origin.分次顺铂和放射治疗对两种起源不同的正常细胞类型的细胞生长和 DNA 损伤积累的影响。

Sci Rep. 2023 Sep 9;13(1):14891. doi: 10.1038/s41598-023-39409-7.

3

evaluation of photon and carbon ion radiotherapy in combination with cisplatin in head and neck squamous cell carcinoma cell lines.头颈部鳞状细胞癌细胞系中光子和碳离子放疗联合顺铂的评估

Front Oncol. 2023 Apr 4;13:896142. doi: 10.3389/fonc.2023.896142. eCollection 2023.

4

Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury.线粒体超氧化物歧化酶与顺铂诱导的肾损伤

Antioxidants (Basel). 2021 Aug 24;10(9):1329. doi: 10.3390/antiox10091329.

5

Targeted infusions of supradose Cisplatin with systemic neutralization for carcinomas invading the temporal bone.针对侵犯颞骨的癌瘤，进行超剂量顺铂的靶向输注并进行全身中和。

Skull Base Surg. 1996;6(2):69-76. doi: 10.1055/s-2008-1058647.

6

Phase I/II study of docetaxel and cisplatin with concurrent thoracic radiation therapy for locally advanced non-small-cell lung cancer.多西他赛和顺铂同步胸部放疗用于局部晚期非小细胞肺癌的I/II期研究

Br J Cancer. 2003 Sep 1;89(5):795-802. doi: 10.1038/sj.bjc.6601217.

7

Radiation therapy combined with radiosensitizing agents for cerebral glioblastoma in adults.成人脑胶质母细胞瘤的放射治疗联合放射增敏剂

J Neurooncol. 1994;19(3):227-37. doi: 10.1007/BF01053276.

8

[Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)].顺二氯二氨合铂（II）。一种源自重金属络合物类的新型抗肿瘤剂（作者译）

Klin Wochenschr. 1979 Dec 3;57(23):1249-58. doi: 10.1007/BF01492980.

本文引用的文献

1

Non-protein sulfhydryl content and cell-cycle dynamics of Ehrlich ascites tumor.艾氏腹水瘤的非蛋白巯基含量与细胞周期动力学

Exp Cell Res. 1969 Jul;56(1):134-41. doi: 10.1016/0014-4827(69)90406-6.

2

Platinum compounds: a new class of potent antitumour agents.铂化合物：一类新型强效抗肿瘤药物。

Nature. 1969 Apr 26;222(5191):385-6. doi: 10.1038/222385a0.

3

Cis-dichlorodiammineplatinum (II). Persistent and selective inhibition of deoxyribonucleic acid synthesis in vivo.顺二氯二氨合铂（II）。体内脱氧核糖核酸合成的持续且选择性抑制。

Biochem Pharmacol. 1970 Oct;19(10):2757-62. doi: 10.1016/0006-2952(70)90102-4.

4

Effect of cis-dichlorodiamine platinum (II) on the post-irradiation lethality in mice after irradiation with X-rays.顺二氯二氨合铂（II）对小鼠X射线照射后辐射致死率的影响。

Strahlentherapie. 1971 Jul;142(1):112-5.

5

Interaction of cis-dichlorodiammineplatinum (II) with DNA.顺二氯二氨合铂（II）与DNA的相互作用。

Biochim Biophys Acta. 1971 Dec 16;254(2):341-7. doi: 10.1016/0005-2787(71)90842-2.

6

New platinum complexes with anti-tumour activity.

Chem Biol Interact. 1972 Nov;5(6):415-24. doi: 10.1016/0009-2797(72)90078-6.

7

Coordination complexes of platinum as antitumor agents.作为抗肿瘤剂的铂配位络合物。

Cancer Chemother Rep. 1975 May-Jun;59(3):629-41.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。