Alvarez M V, Cobreros G, Heras A, Lopez Zumel M C
Br J Cancer Suppl. 1978 Jun;3:68-72.
Cis-dichlorodiammineplatinum (II) (cisDDP) has been extensively studied as an antitumour agent; its binding to DNA has been proved but the radiosensitizing action has scarcely been tested. We report here that on TC.SV -40 mammalian cells cisDPP acts as a dose-modifying factor for ionizing radiation. The radiosensitizing action can be induced by two different mechanisms: reaction with non protein-SH groups and inhibition of repair processes. The cisDDP-DNA complex was studied against increasing radiation doses by analytical centrifugation and by spectrophotometrical measurements. The native complex seems to be more radiation resistant than the denatured one.
顺式二氯二氨合铂（II）（顺铂）作为一种抗肿瘤药物已得到广泛研究；其与DNA的结合已得到证实，但放射增敏作用几乎未被测试。我们在此报告，顺铂对TC.SV -40哺乳动物细胞起到电离辐射剂量修饰因子的作用。放射增敏作用可通过两种不同机制诱导产生：与非蛋白质巯基反应以及抑制修复过程。通过分析离心和分光光度测量，研究了顺铂 - DNA复合物对不断增加的辐射剂量的反应。天然复合物似乎比变性复合物更耐辐射。
