铂配合物作为缺氧哺乳动物细胞的放射增敏剂。
Platinum complexes as radiosensitizers of hypoxic mammalian cells.
作者信息
Douple E B, Richmond R C
出版信息
Br J Cancer Suppl. 1978 Jun;3:98-102.
Abstract
Cis-dichlorodiammineplatinum (II), or cis-PDD, has recently been shown to be a potent radiosensitizer of bacteria, particularly under conditions of acute hypoxia. This study extends this observation to include the radiosensitization of mammalian cell (V-79) by low concentrations of cis-PDD, cis-dichlorobis(aziridine) platinum (II), and the trans-isomer of PDD as measured from survival curve analysis. This radiosensitization was obtained at concentrations of 10 micrometer, 60 micrometer, and 100 micrometer for the cis-PDD, aziridine-platinum, and trans-isomer respectively. The corresponding drug toxicity survival levels were 8, 40 and 50%. Dose modification factors of around 1.3 to 1.4 were observed.
摘要
顺式二氯二氨铂（II），即顺铂，最近已被证明是一种强效的细菌放射增敏剂，尤其是在急性缺氧条件下。本研究将这一观察结果扩展到低浓度顺铂、顺式二氯双（氮丙啶）铂（II）以及通过存活曲线分析测定的顺铂反式异构体对哺乳动物细胞（V - 79）的放射增敏作用。顺铂、氮丙啶铂和顺式异构体的放射增敏作用分别在浓度为10微摩尔、60微摩尔和100微摩尔时获得。相应的药物毒性存活水平分别为8%、40%和50%。观察到剂量修正因子约为1.3至1.4。
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