Love Andrew J, Yu Chulang, Petukhova Natalia V, Kalinina Natalia O, Chen Jianping, Taliansky Michael E
a Cell and Molecular Sciences , James Hutton Institute , Invergowrie, Dundee , UK.
b State Key Laboratory Breeding Base for Sustainable Pest and Disease Control, Key Laboratory of Biotechnology in Plant Protection of MOA and Zhejiang Province , Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences , Hangzhou , China.
RNA Biol. 2017 Jun 3;14(6):779-790. doi: 10.1080/15476286.2016.1243650. Epub 2016 Oct 11.
Cajal bodies (CBs) are distinct sub-nuclear structures that are present in eukaryotic living cells and are often associated with the nucleolus. CBs play important roles in RNA metabolism and formation of RNPs involved in transcription, splicing, ribosome biogenesis, and telomere maintenance. Besides these primary roles, CBs appear to be involved in additional functions that may not be directly related to RNA metabolism and RNP biogenesis. In this review, we assess possible roles of plant CBs in RNA regulatory pathways such as nonsense-mediated mRNA decay and RNA silencing. We also summarize recent progress and discuss new non-canonical functions of plant CBs in responses to stress and disease. It is hypothesized that CBs can regulate these responses via their interaction with poly(ADP ribose)polymerase (PARP), which is known to play an important role in various physiological processes including responses to biotic and abiotic stresses. It is suggested that CBs and their components modify PARP activities and functions.
卡哈尔体（CBs）是真核生物活细胞中存在的独特亚核结构，常与核仁相关。CBs在RNA代谢以及参与转录、剪接、核糖体生物合成和端粒维持的核糖核蛋白（RNPs）形成过程中发挥重要作用。除了这些主要作用外，CBs似乎还参与了一些可能与RNA代谢和RNP生物合成无直接关系的其他功能。在本综述中，我们评估了植物CBs在诸如无义介导的mRNA降解和RNA沉默等RNA调控途径中的可能作用。我们还总结了最近的进展，并讨论了植物CBs在应对胁迫和疾病方面的新的非经典功能。据推测，CBs可通过与聚（ADP核糖）聚合酶（PARP）相互作用来调节这些反应，已知PARP在包括对生物和非生物胁迫的反应在内的各种生理过程中发挥重要作用。有人提出，CBs及其组分可改变PARP的活性和功能。
