Du Jian, Gridneva Zoya, Gay Melvin C L, Trengove Robert D, Hartmann Peter E, Geddes Donna T
School of Chemistry and Biochemistry, The University of Western Australia, 35 Stirling Hwy, Perth, Western Australia, 6009, Australia.
School of Chemistry and Biochemistry, The University of Western Australia, 35 Stirling Hwy, Perth, Western Australia, 6009, Australia.
Chemosphere. 2017 Jan;167:247-254. doi: 10.1016/j.chemosphere.2016.10.005. Epub 2016 Oct 8.
Persistent organic pollutants in human milk (HM) at high levels are considered to be detrimental to the breastfed infant. To determine the pesticide concentration in HM, a pilot cross-sectional study of 40 Western Australian (WA) women was carried out. Gas chromatography-tandem mass spectrometry (GC-MS/MS) with a validated QuEChERS was used for the analysis of 88 pesticides in HM. p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) with a mean concentration of 62.8 ± 54.5 ng/g fat was found, whereas other organochlorines, organophosphates, carbamates and pyrethroids were not detected in HM. Overall, no association was observed between HM p,p'-DDE concentrations and maternal age, parity, body mass index and percentage fat mass. Furthermore, for the first time no significant association was found between p,p'-DDE concentrations in HM and infant growth outcomes such as weight, length, head circumference and percentage fat mass. The calculated daily intake was significantly different to the estimated daily intake of total DDTs and was well below the guideline proposed by WHO. The DDTs levels in WA have also significantly decreased by 42 - fold since the 1970s and are currently the lowest in Australia.
母乳中高水平的持久性有机污染物被认为对母乳喂养的婴儿有害。为了确定母乳中的农药浓度，对40名西澳大利亚州（WA）女性进行了一项试点横断面研究。采用经过验证的QuEChERS方法结合气相色谱 - 串联质谱法（GC-MS/MS）分析母乳中的88种农药。发现对，对'-二氯二苯二氯乙烯（p，p'-DDE）的平均浓度为62.8±54.5 ng/g脂肪，而母乳中未检测到其他有机氯、有机磷、氨基甲酸酯和拟除虫菊酯。总体而言，母乳中p，p'-DDE浓度与产妇年龄、胎次、体重指数和体脂百分比之间未观察到关联。此外，首次发现母乳中p，p'-DDE浓度与婴儿生长指标如体重、身长、头围和体脂百分比之间无显著关联。计算出 的每日摄入量与总滴滴涕的估计每日摄入量显著不同，且远低于世界卫生组织提出的指导值。自20世纪70年代以来，西澳大利亚州的滴滴涕水平也显著下降了42倍，目前是澳大利亚最低的。
