Velázquez-Pérez Luis, Tünnerhoff Johannes, Rodríguez-Labrada Roberto, Torres-Vega Reidenis, Belardinelli Paolo, Medrano-Montero Jacqueline, Peña-Acosta Arnoy, Canales-Ochoa Nalia, Vázquez-Mojena Yaimeé, González-Zaldivar Yanetza, Auburger Georg, Ziemann Ulf
Department Clinical Neurophysiology, Centre for the Research and Rehabilitation of Hereditary Ataxias, Calle Libertad 26, Holguín, Cuba, 80100.
Department Neurology & Stroke, and Hertie Institute for Clinical Brain Research, University Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
Cerebellum. 2017 Apr;16(2):602-606. doi: 10.1007/s12311-016-0827-4.
Clinical signs of corticospinal tract dysfunction are a common feature of spinocerebellar ataxia type 2 (SCA2) patients. The objective of this study is to assess dysfunction of the corticospinal tract in SCA2 using corticomuscular coherence. Testing corticomuscular coherence and rating of ataxia severity and non-ataxia symptoms were performed in 19 SCA2 patients and 24 age-matched controls. Central motor conduction times (CMCT) to upper and lower right limbs were obtained for the SCA2 group using Transcraneal magnetic stimulation (TMS). SCA2 patients exhibited a significant reduction of corticomuscular coherence for lower limbs, but not for upper limbs. This difference remained significant, even when excluding those individuals with clinical signs of corticospinal tract dysfunction. Corticomuscular coherence for lower limbs correlated inversely with CMCT to tibialis anterior muscle. Corticomuscular coherence could be a valuable electrophysiological tool to assess the corticospinal tract involvement in SCA2, even in the absence of clinical signs of corticospinal tract dysfunction.
皮质脊髓束功能障碍的临床体征是2型脊髓小脑共济失调（SCA2）患者的常见特征。本研究的目的是使用皮质肌肉相干性评估SCA2患者皮质脊髓束的功能障碍。对19例SCA2患者和24例年龄匹配的对照者进行了皮质肌肉相干性测试以及共济失调严重程度和非共济失调症状的评分。使用经颅磁刺激（TMS）为SCA2组获得了右侧上下肢的中枢运动传导时间（CMCT）。SCA2患者下肢的皮质肌肉相干性显著降低，但上肢未出现这种情况。即使排除那些有皮质脊髓束功能障碍临床体征的个体，这种差异仍然显著。下肢的皮质肌肉相干性与胫前肌的CMCT呈负相关。即使在没有皮质脊髓束功能障碍临床体征的情况下，皮质肌肉相干性也可能是评估SCA2患者皮质脊髓束受累情况的有价值的电生理工具。
