Lopes Vinicius Medina, Lopes Joaquim Roberto Costa, Brasileiro Jean Pierre Barguil, Oliveira Ingrid de, Lacerda Ricardo Peclat, Andrade Marcos Renato Dib, Tierno Natália Ivet Zavattiero, Souza Roberto Costa Cavalcante de, Motta Luiz Augusto Casulari Roxo da
Departamento de Reprodução Humana, Instituto de Vídeo Endoscopia e Reprodução Humana (VERHUM), Brasília, DF, Brasil.
Departamento de Reprodução Humana, Centro de Medicina Reprodutiva (Cenafert), Salvador, BA, Brasil.
Arch Endocrinol Metab. 2017 Jan-Feb;61(1):21-27. doi: 10.1590/2359-3997000000216. Epub 2016 Oct 10.
Vitamin D has several metabolic functions and possible reproductive functions. This study aimed to determine the prevalence of vitamin D deficiency among Brazilian women of reproductive age, and to evaluate the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and infertility causes.
This retrospective cross-sectional study evaluated data from a private Brazilian assisted reproduction center that were collected between January 1 and May 5, 2012. Serum 25(OH)D concentrations were measured and compared for infertile and fertile women. Concentrations of 25(OH)D that were < 20 ng/mL were defined as deficiency and concentrations of 21-30 ng/mL were defined as hypovitaminosis D.
Among the 369 evaluated women, 81.1% exhibited hypovitaminosis D and 32.0% exhibited deficiency. The infertile and control patients did not exhibit any significant differences in the prevalence of vitamin D deficiency (30.2% vs. 35%, respectively; p = 0.33) or in the mean 25(OH)D concentrations (24.3 ± 7.9 ng/mL vs. 23.8 ± 8.7 ng/mL, respectively; p = 0.51). Furthermore, there were no significant differences in the mean 25(OH)D concentrations among subgroups of patients with single infertility factors, or between these subgroups and the control group.
A high proportion of Brazilian women of reproductive age exhibited vitamin D deficiency, regardless of their fertility status. Thus, it may be useful to evaluate this population for vitamin D deficiency, although future studies are needed to determine whether this deficiency might affect the outcomes of treatments for infertility.
维生素D具有多种代谢功能及可能的生殖功能。本研究旨在确定巴西育龄女性维生素D缺乏的患病率，并评估血清25-羟基维生素D[25(OH)D]浓度与不孕原因之间的关系。
这项回顾性横断面研究评估了巴西一家私立辅助生殖中心在2012年1月1日至5月5日期间收集的数据。测量并比较了不孕女性和可育女性的血清25(OH)D浓度。25(OH)D浓度<20 ng/mL被定义为缺乏，21-30 ng/mL的浓度被定义为维生素D不足。
在369名接受评估的女性中，81.1%表现为维生素D不足，32.0%表现为缺乏。不孕患者和对照患者在维生素D缺乏患病率（分别为30.2%和35%；p = 0.33）或平均25(OH)D浓度（分别为24.3±7.9 ng/mL和23.8±8.7 ng/mL；p = 0.51）方面没有显著差异。此外，单一不孕因素患者亚组之间以及这些亚组与对照组之间的平均25(OH)D浓度也没有显著差异。
无论生育状况如何，高比例的巴西育龄女性存在维生素D缺乏。因此，对这一人群进行维生素D缺乏评估可能是有用的，尽管需要进一步研究来确定这种缺乏是否会影响不孕症治疗的结果。
