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白色念珠菌起搏器导线心内膜炎:一例报告

Candida albicans Pacemaker Lead Endocarditis: A Case Report.

作者信息

Karrati Siham, Mhirig Ibtissam, Baiya Mahjouba, El Hakkouni Awatif

机构信息

Biology Department/Parasitology-Mycology Laboratory, Mohammed VI University Hospital/Faculty of Medicine and Pharmacy-Cadi Ayyad University, Marrakech, MAR.

出版信息

Cureus. 2025 Feb 28;17(2):e79824. doi: 10.7759/cureus.79824. eCollection 2025 Feb.

DOI:10.7759/cureus.79824
PMID:40161077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11955200/
Abstract

Fungal endocarditis (FE) is a rare yet potentially life-threatening complication of permanent cardiac pacing, most commonly caused by species of the genera and . The diagnosis is challenging, as the clinical presentation of FE is usually nonspecific and insidious. A high level of clinical suspicion is required, particularly in patients with implantable pacemakers presenting with unexplained fever. Early diagnosis is crucial for effective and prompt management, which generally relies on a combined medical and surgical approach. We report a case of fungal pacemaker lead endocarditis caused by Candida albicans in a 68-year-old man, which was successfully treated with a multidisciplinary approach combining surgical explantation and antifungal therapy.

摘要

真菌性心内膜炎(FE)是永久性心脏起搏罕见但可能危及生命的并发症,最常见的病因是 属和 属的菌种。FE的诊断具有挑战性,因为其临床表现通常不具特异性且隐匿。需要高度的临床怀疑,特别是对于植入起搏器且出现不明原因发热的患者。早期诊断对于有效和及时的治疗至关重要,治疗通常依赖于药物和手术相结合的方法。我们报告了一例68岁男性由白色念珠菌引起的真菌性起搏器导线心内膜炎病例,该病例通过手术取出导线和抗真菌治疗相结合的多学科方法成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3384/11955200/242270420cba/cureus-0017-00000079824-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3384/11955200/8819c53b0bcd/cureus-0017-00000079824-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3384/11955200/db55b35df431/cureus-0017-00000079824-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3384/11955200/242270420cba/cureus-0017-00000079824-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3384/11955200/8819c53b0bcd/cureus-0017-00000079824-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3384/11955200/db55b35df431/cureus-0017-00000079824-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3384/11955200/242270420cba/cureus-0017-00000079824-i03.jpg

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本文引用的文献

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Echocardiography in Endocarditis.超声心动图在心内膜炎中的应用。
Echocardiography. 2024 Oct;41(10):e15945. doi: 10.1111/echo.15945.
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Infective endocarditis.感染性心内膜炎。
Lancet. 2024 Jul 27;404(10450):377-392. doi: 10.1016/S0140-6736(24)01098-5.
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Publication Trends on Infective Endocarditis: Comprehensive Bibliometric Analysis and Visualization Between 1892 and 2022.感染性心内膜炎的出版趋势:1892年至2022年间的综合文献计量分析与可视化
Anatol J Cardiol. 2024 Mar 20;28(5):245-54. doi: 10.14744/AnatolJCardiol.2024.4277.
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Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management.真菌性心内膜炎:病理生理学、流行病学、临床表现、诊断和治疗。
Clin Microbiol Rev. 2023 Sep 21;36(3):e0001923. doi: 10.1128/cmr.00019-23. Epub 2023 Jul 13.
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Antifungal Resistance of Clinical Isolates in Iran: A Systematic Review and Meta-Analysis.伊朗临床分离株的抗真菌耐药性:一项系统评价和荟萃分析。
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Candida Endocarditis: A Review of the Pathogenesis, Morphology, Risk Factors, and Management of an Emerging and Serious Condition.念珠菌性心内膜炎:一种新发严重疾病的发病机制、形态学、危险因素及治疗综述
Cureus. 2020 Jan 18;12(1):e6695. doi: 10.7759/cureus.6695.
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Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal.血流感染中的抗真菌耐药性与耐受性:酵母-宿主-抗真菌三联体
Microorganisms. 2020 Jan 22;8(2):154. doi: 10.3390/microorganisms8020154.
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Fungal endocarditis: what do we know in 2019?真菌性心内膜炎:2019 年我们了解多少?
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[Infective endocarditis and specific situations: Right heart, valve prosthesis, cardiac implantable electronic device].[感染性心内膜炎与特殊情况:右心、人工瓣膜、心脏植入式电子装置]
Presse Med. 2019 May;48(5):549-555. doi: 10.1016/j.lpm.2019.04.006. Epub 2019 May 17.
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Fungal Endocarditis.真菌性心内膜炎
Braz J Cardiovasc Surg. 2016 May-Jun;31(3):252-255. doi: 10.5935/1678-9741.20160026.