Criqui Michael H, Aboyans Victor, Allison Matthew A, Denenberg Julie O, Forbang Nketi, McDermott Mary M, Wassel Christina L, Wong Nathan D
Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Department of Cardiology, Dupuytren University Hospital, Limoges, France; Inserm 1094, Tropical Neuroepidemiology, University of Limoges, Limoges, France.
Glob Heart. 2016 Sep;11(3):313-326. doi: 10.1016/j.gheart.2016.08.005.
We reviewed published MESA (Multi-Ethnic Study of Atherosclerosis) study articles concerning peripheral arterial disease, subclavian stenosis (SS), abdominal aortic calcium (AAC), and thoracic artery calcium (TAC). Important findings include, compared to non-Hispanic whites, lower ankle-brachial index (ABI) and more SS in African Americans, and higher ABI and less SS in Hispanic and Chinese Americans. Abnormal ABI and brachial pressure differences were associated with other subclinical cardiovascular disease (CVD) measures. Both very high and low ABI independently predicted increased CVD events. Looking at aortic measures, TAC and AAC were significantly associated with other subclinical CVD measures. Comparisons of AAC with coronary artery calcium (CAC) showed that both were less common in ethnic minority groups. However, although CAC was much more common in men than in women in multivariable analysis, this was not true of AAC. Also, when AAC and CAC were adjusted for each other in multivariable analysis, there was a stronger association for AAC than for CAC with CVD and total mortality.
我们回顾了已发表的关于外周动脉疾病、锁骨下狭窄（SS）、腹主动脉钙化（AAC）和胸动脉钙化（TAC）的动脉粥样硬化多民族研究（MESA）文章。重要发现包括，与非西班牙裔白人相比，非裔美国人的踝臂指数（ABI）较低且SS较多，而西班牙裔和华裔美国人的ABI较高且SS较少。异常的ABI和肱动脉压差与其他亚临床心血管疾病（CVD）指标相关。极高和极低的ABI均独立预测CVD事件增加。观察主动脉指标，TAC和AAC与其他亚临床CVD指标显著相关。AAC与冠状动脉钙化（CAC）的比较表明，两者在少数族裔群体中都较少见。然而，尽管在多变量分析中CAC在男性中比在女性中更为常见，但AAC并非如此。此外，在多变量分析中当对AAC和CAC进行相互调整时，与CVD和总死亡率相比，AAC的关联比CAC更强。
