类风湿关节炎患者使用青霉胺相关的肝毒性。
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.
作者信息
Rosenbaum J, Katz W A, Schumacher H R
出版信息
Ann Rheum Dis. 1980 Apr;39(2):152-4. doi: 10.1136/ard.39.2.152.
Abstract
Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine. Both recovered after withdrawal of the drug. These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.
摘要
两名类风湿性关节炎患者在接受青霉胺治疗时出现了肝毒性迹象。停药后两人均康复。这些病例以及对文献的回顾表明，肝毒性虽然罕见，但应被列入青霉胺不良反应清单中。
相似文献
1
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.类风湿关节炎患者使用青霉胺相关的肝毒性。
Ann Rheum Dis. 1980 Apr;39(2):152-4. doi: 10.1136/ard.39.2.152.
2
[Granulomatous hepatitis and parotiditis induced by d-penicillamine in a case of rheumatoid arthritis].[类风湿关节炎患者中d-青霉胺诱发的肉芽肿性肝炎和腮腺炎]
Nouv Presse Med. 1979 Jan 20;8(3):212.
3
D-penicillamine-induced acute hypersensitivity pneumonitis and cholestatic hepatitis in a patient with rheumatoid arthritis.青霉胺诱发的类风湿关节炎患者急性过敏性肺炎和胆汁淤积性肝炎
Clin Exp Rheumatol. 1985 Oct-Dec;3(4):337-9.
4
A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis.
Int J Clin Pharmacol Res. 1985;5(1):35-8.
5
Liver abnormalities in penicillamine treated rheumatoid arthritis.青霉胺治疗类风湿关节炎时的肝脏异常
Scand J Rheumatol Suppl. 1979(28):100-7. doi: 10.3109/03009747909108248.
6
Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis.
Ann Intern Med. 1983 Mar;98(3):327-30. doi: 10.7326/0003-4819-98-3-327.
7
Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.与青霉胺治疗类风湿关节炎相关的重症肌无力。
Br Med J. 1975 Mar 15;1(5958):600-2. doi: 10.1136/bmj.1.5958.600.
8
Toxic hepatitis after therapeutic doses of benorylate and D-penicillamine.
Lancet. 1977 Feb 26;1(8009):481-2. doi: 10.1016/s0140-6736(77)91965-1.
9
Dermatomyositis induced by penicillamine.
Acta Derm Venereol. 1979;59(6):543-4.
10
Penicillamine treatment in rheumatoid arthritis. A retrospective study.青霉胺治疗类风湿性关节炎。一项回顾性研究。
Acta Med Scand. 1980;207(1-2):93-6. doi: 10.1111/j.0954-6820.1980.tb09683.x.
引用本文的文献
1
D-penicillamine-induced granulomatous hepatitis in brown Norway rats.D-青霉胺诱导的棕色挪威大鼠肉芽肿性肝炎。
Mol Cell Biochem. 2014 Aug;393(1-2):229-35. doi: 10.1007/s11010-014-2065-8. Epub 2014 Apr 27.
2
Clinical associations between arthritis and liver disease.关节炎与肝脏疾病之间的临床关联。
Ann Rheum Dis. 1982 Jun;41(3):295-307. doi: 10.1136/ard.41.3.295.
3
Raised serum alkaline phosphatase and aspartate transaminase levels in two rheumatoid patients treated with sulphasalazine.两名接受柳氮磺胺吡啶治疗的类风湿患者血清碱性磷酸酶和天冬氨酸转氨酶水平升高。
Ann Rheum Dis. 1985 Nov;44(11):798-800. doi: 10.1136/ard.44.11.798.
4
Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.青霉胺治疗类风湿关节炎导致的致命性再生障碍性贫血和肝毒性。
Ann Rheum Dis. 1989 Jul;48(7):609-10. doi: 10.1136/ard.48.7.609.
5
Azathioprine induced hepatic veno-occlusive disease in rheumatoid arthritis.硫唑嘌呤诱发类风湿关节炎患者发生肝静脉闭塞病。
Ann Rheum Dis. 1989 Apr;48(4):342-6. doi: 10.1136/ard.48.4.342.
本文引用的文献
1
[Allergic-toxic liver damage due to D-penicillamine].
Schweiz Med Wochenschr. 1972 Aug 26;102(34):1226-8.
2
[Intrahepatic cholestasis following treatment with D-penicillamine and indomethacin].[D-青霉胺和吲哚美辛治疗后发生的肝内胆汁淤积]
Med Welt. 1976 Jan 23;27(4):172-3.
3
[Severe side-effects of treatment with D-penicillamine (author's transl)].
Dtsch Med Wochenschr. 1975 Aug 8;100(32):1634-8. doi: 10.1055/s-0028-1106435.
4
Letter: Aspirin hepatotoxicity.
Ann Intern Med. 1975 Apr;82(4):592-3. doi: 10.7326/0003-4819-82-4-592_2.
5
D-penicillamine.
Bull Rheum Dis. 1977;28(6):948-52.
6
Cholestatic jaundice caused by D-penicillamine.青霉胺引起的胆汁淤积性黄疸。
Ann Rheum Dis. 1978 Feb;37(1):98-100. doi: 10.1136/ard.37.1.98.
7
Toxicity of D-penicillamine in rheumatoid arthritis. A report of 63 patients including two with aplastic anemia and one with the nephrotic syndrome.
Am J Med. 1978 Jan;64(1):114-20. doi: 10.1016/0002-9343(78)90186-9.
8
Toxic hepatitis after therapeutic doses of benorylate and D-penicillamine.
Lancet. 1977 Feb 26;1(8009):481-2. doi: 10.1016/s0140-6736(77)91965-1.
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