生物活性γ-内酰胺：合成与天然来源
Biologically active γ-lactams: synthesis and natural sources.
作者信息
Caruano J, Muccioli G G, Robiette R
机构信息
Institute of Condensed Matter and Nanosciences, Université catholique de Louvain, Place Louis Pasteur 1 box L4.01.02, 1348 Louvain-la-Neuve, Belgium.
Louvain Drug Research Institute, Université catholique de Louvain, Av. E. Mounier 73 box B1.72.01, 1200 Brussels, Belgium.
出版信息
Org Biomol Chem. 2016 Nov 2;14(43):10134-10156. doi: 10.1039/c6ob01349j.
The γ-lactam moiety is present in a large number of natural and non-natural biologically active compounds. The range of biological activities covered by these compounds is very broad. Functionalized γ-lactams are thus of high interest and have great potential in medicinal chemistry. This review provides a description of the title compounds by focusing on their synthesis, natural sources and biological activities.
γ-内酰胺部分存在于大量天然和非天然的生物活性化合物中。这些化合物涵盖的生物活性范围非常广泛。因此，功能化的γ-内酰胺备受关注，在药物化学中具有巨大潜力。本综述通过聚焦其合成、天然来源和生物活性来描述标题化合物。
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