通过静磁场增强癌细胞的冷大气等离子体处理
Enhancing cold atmospheric plasma treatment of cancer cells by static magnetic field.
作者信息
Cheng Xiaoqian, Rajjoub Kenan, Shashurin Alexey, Yan Dayun, Sherman Jonathan H, Bian Ka, Murad Ferid, Keidar Michael
机构信息
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, District of Columbia.
Columbian College of Arts and Sciences, The George Washington University, Washington, District of Columbia.
出版信息
Bioelectromagnetics. 2017 Jan;38(1):53-62. doi: 10.1002/bem.22014. Epub 2016 Oct 17.
It has been reported since late 1970 that magnetic field interacts strongly with biological systems. Cold atmospheric plasma (CAP) has also been widely studied over the past few decades in physics, biology, and medicine. In this study, we propose a novel idea to combine static magnetic field (SMF) with CAP as a tool for cancer therapy. Breast cancer cells and wild type fibroblasts were cultured in 96-well plates and treated by CAP with or without SMF. Breast cancer cells MDA-MB-231 showed a significant decrease in viability after direct plasma treatment with SMF (compared to only plasma treatment). In addition, cancer cells treated by the CAP-SMF-activated medium (indirect treatment) also showed viability decrease but was slightly weaker than the direct plasma-SMF treatment. By integrating the use of SMF and CAP, we were able to discover their advantages that have yet to be utilized. Bioelectromagnetics. 38:53-62, 2017. © 2016 Wiley Periodicals, Inc.
自1970年末以来，已有报道称磁场与生物系统存在强烈相互作用。在过去几十年里，冷大气等离子体（CAP）在物理学、生物学和医学领域也得到了广泛研究。在本研究中，我们提出了一种将静磁场（SMF）与CAP相结合作为癌症治疗工具的新想法。将乳腺癌细胞和野生型成纤维细胞培养在96孔板中，并用有或无SMF的CAP进行处理。乳腺癌细胞MDA-MB-231在经SMF直接等离子体处理后（与仅进行等离子体处理相比）活力显著下降。此外，经CAP-SMF激活培养基处理的癌细胞（间接处理）活力也下降，但比直接等离子体-SMF处理稍弱。通过整合SMF和CAP的使用，我们能够发现它们尚未被利用的优势。《生物电磁学》。2017年第38卷：53 - 62页。© 2016威利期刊公司。
Zotero 插件