Truong James Q, Ciuffreda Kenneth J
Department of Biological and Vision Sciences, SUNY College of Optometry, 33 West 42nd Street, New York, NY, 10036.
Mil Med. 2016 Oct;181(10):1382-1390. doi: 10.7205/MILMED-D-15-00587.
No objective vision biomarker for photosensitivity currently exists. The present study sought to uncover potential biomarkers for photosensitivity within the pupillary light reflex.
The pupillary light reflex was evaluated in those with mild traumatic brain injury (mTBI) and in normal individuals, with and without photosensitivity, under a range of test conditions. The Neuroptics DP-2000, infrared, binocular pupillometer was used for both binocular stimulation and recording. Twelve pupil parameters and 6 stimulus conditions were quantitatively assessed in 32 adults with mTBI and compared to 40 normal adult controls.
Normal subjects with photosensitivity exhibited four significant differences (p < 0.05) as compared with their nonphotosensitive cohort: larger constriction amplitude, faster average constriction velocity, faster peak constriction velocity, and slower recovery time. mTBI subjects with photosensitivity manifested six significant differences (p < 0.05) as compared with their nonphotosensitive cohort: larger baseline diameter, larger minimum diameter, faster peak dilation velocity, faster T50 and T75 recovery times, and a larger pupil diameter at 6 seconds poststimulus.
Several pupillometry parameters were significantly different in those with and without photosensitivity in both populations tested. These specific parameters could serve as potential, objectively based biomarkers for photosensitivity in these specific populations.
目前尚无用于光敏性的客观视觉生物标志物。本研究旨在揭示瞳孔对光反射中光敏性的潜在生物标志物。
在一系列测试条件下，对患有轻度创伤性脑损伤（mTBI）的患者以及有或没有光敏性的正常个体的瞳孔对光反射进行评估。使用Neuroptics DP - 2000型红外双目瞳孔测量仪进行双目刺激和记录。对32名患有mTBI的成年人的12个瞳孔参数和6种刺激条件进行了定量评估，并与40名正常成年人对照组进行比较。
有光敏性的正常受试者与其无光敏性的队列相比，表现出四个显著差异（p < 0.05）：收缩幅度更大、平均收缩速度更快、峰值收缩速度更快以及恢复时间更慢。有光敏性的mTBI受试者与其无光敏性的队列相比，表现出六个显著差异（p < 0.05）：基线直径更大、最小直径更大、峰值扩张速度更快、T50和T75恢复时间更快，以及刺激后6秒时瞳孔直径更大。
在测试的两个群体中，有和没有光敏性的个体在几个瞳孔测量参数上存在显著差异。这些特定参数可作为这些特定人群中基于客观指标的光敏性潜在生物标志物。
