Thylur David S, Jacobs Russell E, Go John L, Toga Arthur W, Niparko John K
*USC Tina and Rick Caruso Department of Otolaryngology-Head & Neck Surgery †Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena ‡Department of Radiology §Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California.
Otol Neurotol. 2017 Jan;38(1):133-138. doi: 10.1097/MAO.0000000000001242.
To evaluate the ability of ultra-high-field magnetic resonance imaging (UHF-MRI) at 11.7 T to visualize membranous structures of the human inner ear.
Three temporal bones were extracted from cadaveric human heads for use with small-bore UHF-MRI.
Ex vivo cadaveric temporal bone specimens were imaged using an 11.7 T magnetic resonance imaging (MRI) scanner via T1- and T2-weighted-imaging with and without contrast.
Qualitative visualization of membranous components of the inner ear compared with reports of UHF-MRI at lower field strengths.
The membranous anatomy of the inner ear was superbly visualized at 11.7 T. In the cochlea, Reissner's membrane, the scala media, and the basilar membrane were clearly shown on the scan. In the vestibular labyrinth, the wedge-shaped crista ampullaris and the maculae of both the saccule and utricle were visible. Details of the endolymphatic sac and duct were also demonstrated.
To our knowledge, this report presents the first images of the ex vivo human inner ear using 11.7 T UHF-MRI, offering near-histologic resolution. Increased field strength may be particularly useful when imaging the delicate membranous anatomy of the inner ear. Further research on the use of UHF-MRI in clinical and research settings could illuminate structural changes associated with inner ear disorders.
评估11.7T超高场磁共振成像（UHF-MRI）可视化人内耳膜性结构的能力。
从尸体头部提取三块颞骨用于小口径UHF-MRI。
使用11.7T磁共振成像（MRI）扫描仪，通过有或无对比剂的T1加权成像和T2加权成像对离体尸体颞骨标本进行成像。
将内耳膜性成分的定性可视化结果与低场强UHF-MRI的报告结果进行比较。
在11.7T时，内耳的膜性解剖结构得到了极佳的可视化。在耳蜗中，扫描清晰显示了Reissner膜、中阶和基底膜。在前庭迷路中，可见楔形壶腹嵴以及球囊和椭圆囊的斑。内淋巴囊和内淋巴管的细节也得到了显示。
据我们所知，本报告展示了使用11.7T UHF-MRI获得的离体人内耳的首批图像，提供了接近组织学的分辨率。在对内耳精细的膜性解剖结构进行成像时，增加场强可能特别有用。关于UHF-MRI在临床和研究环境中的应用的进一步研究，可能会揭示与内耳疾病相关的结构变化。
