Schoenau E, Boeswald W, Wanner R, Herzog K H, Boewing B, Boehles H J, Stehr K
Klinik mit Poliklinik für Kinder und Jugendliche der Friedrich-Alexander Universität Erlangen-Nürnberg, F.R.G.
Clin Chem. 1989 Sep;35(9):1888-90.
The high-Mr isoenzyme of alkaline phosphatase (AP, EC 3.1.3.1), a highly sensitive index to cholestasis, was measured by liquid chromatography in 45 patients with cystic fibrosis. Results of serum tests for liver dysfunction--including gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase, total AP, bilirubin, and bile acids--were compared with those for high-Mr AP. Values for high-Mr AP were increased in 44.4% of our patient population, with activities ranging from 0.4 to 17.3 U/L. The upper limit in the control group was 2.5 U/L. We find increased high-Mr AP to be a more sensitive indicator of liver dysfunction in patients with cystic fibrosis than are other tests.
