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国家迈向消除丙型肝炎的进展 - 乔治亚州,2015-2016 年。

National Progress Toward Hepatitis C Elimination - Georgia, 2015-2016.

出版信息

MMWR Morb Mortal Wkly Rep. 2016 Oct 21;65(41):1132-1135. doi: 10.15585/mmwr.mm6541a2.

Abstract

The country of Georgia has a high prevalence of hepatitis C virus (HCV) infection, associated with exposures to HCV in health care settings with inadequate infection control and unsafe injections among persons who inject drugs (1). In April 2015, in collaboration with CDC and other partners, Georgia embarked on a program to eliminate HCV infection, subsequently defined as achieving a 90% reduction in prevalence by 2020. The initial phase of the program focused on providing HCV treatment to infected persons with advanced liver disease and at highest risk for HCV-associated morbidity and mortality. By April 27, 2016, a total of 27,392 HCV-infected persons registered for the program, 8,448 (30.8%) started treatment, and 5,850 patients (69.2%) completed HCV treatment. Among patients completing treatment who were eligible for posttreatment testing, 2,398 received polymerase chain reaction (PCR) testing for HCV at least 12 weeks after completion of treatment; 1,980 (82.6%) had no detectable virus, indicative of a sustained virologic response* (i.e., cure). Major challenges to achieving elimination remain, including the need to increase access to care and treatment services and implement a comprehensive approach to prevention and control of HCV infection. As a global leader in this effort, the Georgia HCV Elimination Program can help pave the way for other countries experiencing high rates of HCV infection to undertake similar initiatives.

摘要

格鲁吉亚是丙型肝炎病毒 (HCV) 感染高发国家,这与卫生保健环境中感染控制措施不足导致的 HCV 暴露以及注射吸毒者不安全注射有关(1)。2015 年 4 月,格鲁吉亚与美国疾病预防控制中心和其他合作伙伴合作,启动了消除 HCV 感染的计划,随后将其定义为到 2020 年实现 HCV 流行率降低 90%。该计划的初始阶段侧重于为患有晚期肝病和感染 HCV 后发病率和死亡率最高的高危人群提供 HCV 治疗。截至 2016 年 4 月 27 日,共有 27392 名 HCV 感染者登记参加该计划,8448 人(30.8%)开始治疗,5850 名患者(69.2%)完成 HCV 治疗。在符合条件进行治疗后检测的完成治疗的患者中,有 2398 人在完成治疗至少 12 周后接受了 HCV 聚合酶链反应(PCR)检测;1980 人(82.6%)未检测到病毒,表明持续病毒学应答*(即治愈)。实现消除的主要挑战仍然存在,包括需要增加获得护理和治疗服务的机会,并实施综合办法预防和控制 HCV 感染。作为这方面的全球领导者,格鲁吉亚 HCV 消除计划可以为其他感染率高的国家开展类似的举措提供借鉴。

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