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筛查与治疗在格鲁吉亚迈向消除丙型肝炎国家进程中的作用 - 2015 - 2016年

The Role of Screening and Treatment in National Progress Toward Hepatitis C Elimination - Georgia, 2015-2016.

作者信息

Nasrullah Muazzam, Sergeenko David, Gvinjilia Lia, Gamkrelidze Amiran, Tsertsvadze Tengiz, Butsashvili Maia, Metreveli David, Sharvadze Lali, Alkhazashvili Maia, Shadaker Shaun, Ward John W, Morgan Juliette, Averhoff Francisco

出版信息

MMWR Morb Mortal Wkly Rep. 2017 Jul 28;66(29):773-776. doi: 10.15585/mmwr.mm6629a2.

Abstract

Georgia, a country in the Caucasus region of Eurasia, has a high prevalence of hepatitis C virus (HCV) infection. In April 2015, with technical assistance from CDC, Georgia embarked on the world's first program to eliminate hepatitis C, defined as a 90% reduction in HCV prevalence by 2020 (1,2). The country committed to identifying infected persons and linking them to care and curative antiviral therapy, which was provided free of charge through a partnership with Gilead Sciences (1,2). From April 2015 through December 2016, a total of 27,595 persons initiated treatment for HCV infection, among whom 19,778 (71.7%) completed treatment. Among 6,366 persons tested for HCV RNA ≥12 weeks after completing treatment, 5,356 (84.1%) had no detectable virus in their blood, indicative of a sustained virologic response (SVR) and cure of HCV infection. The number of persons initiating treatment peaked in September 2016 at 4,595 and declined during October-December. Broader implementation of interventions that increase access to HCV testing, care, and treatment for persons living with HCV are needed for Georgia to reach national targets for the elimination of HCV.

摘要

格鲁吉亚是欧亚大陆高加索地区的一个国家,丙型肝炎病毒(HCV)感染率很高。2015年4月,在疾病控制与预防中心(CDC)的技术援助下,格鲁吉亚启动了世界上首个消除丙型肝炎的项目,目标是到2020年将HCV感染率降低90%(1,2)。该国致力于识别感染者,并将他们与护理及抗病毒治疗相联系,抗病毒治疗通过与吉利德科学公司合作免费提供(1,2)。从2015年4月到2016年12月,共有27595人开始接受HCV感染治疗,其中19778人(71.7%)完成了治疗。在完成治疗后≥12周接受HCV RNA检测的6366人中,5356人(84.1%)血液中未检测到病毒,表明有持续病毒学应答(SVR)且HCV感染已治愈。开始治疗的人数在2016年9月达到峰值,为4595人,在10月至12月期间有所下降。格鲁吉亚要实现消除HCV的国家目标,需要更广泛地实施干预措施,以增加HCV感染者获得检测、护理和治疗的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f2a/5657814/9cfe28eb2837/mm6629a2-F1.jpg

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