Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Endocrinology, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Mol Cell Endocrinol. 2017 Dec 5;457:49-56. doi: 10.1016/j.mce.2016.10.017. Epub 2016 Oct 17.
Certain environmental chemicals may accumulate in human serum and tissues eliciting estrogenic and/or carcinogenic effects. Therefore, there is heightened interest in determining whether environmental chemicals may increase the risk for endocrine-related tumors like breast cancer. For instance, metals as cadmium, zinc, copper, iron, nickel and aluminum have been shown to mimic estrogen action. Moreover, the exposure to these chemicals has been reported to stimulate diverse malignancies including breast cancer, which is the most common tumor in women worldwide. In this review, we summarize the epidemiologic and experimental evidence regarding the association between the exposure to some trace elements and breast cancer risk. We also address recent insights on the molecular mechanisms involved by metals in breast tumorigenesis.
某些环境化学物质可能会在人体血清和组织中积累，引发雌激素和/或致癌作用。因此，人们越来越关注环境化学物质是否会增加乳腺癌等与内分泌相关的肿瘤的风险。例如，已经证明某些金属，如镉、锌、铜、铁、镍和铝，具有模拟雌激素作用的能力。此外，据报道，这些化学物质的暴露会刺激多种恶性肿瘤，包括乳腺癌，这是全世界女性最常见的肿瘤。在这篇综述中，我们总结了关于某些微量元素暴露与乳腺癌风险之间关联的流行病学和实验证据。我们还讨论了金属在乳腺癌发生中的分子机制的最新见解。
