Ventura Maria I, Barnes Deborah E, Ross Jessica M, Lanni Kimberly E, Sigvardt Karen A, Disbrow Elizabeth A
Department of Epidemiology & Biostatistics, UC, San Francisco, CA, United States.
Department of Epidemiology & Biostatistics, UC, San Francisco, CA, United States; Department of Psychiatry, UC San Francisco, San Francisco, CA, United States; Mental Health Research Service, San Francisco VA Medical Center, San Francisco, CA, United States.
Contemp Clin Trials. 2016 Nov;51:50-55. doi: 10.1016/j.cct.2016.10.001. Epub 2016 Oct 17.
Parkinson's disease (PD) is a progressive neurodegenerative disease associated with deficits in motor, cognitive, and emotion/quality of life (QOL) domains, yet most pharmacologic and behavioral interventions focus only on motor function. Our goal was to perform a pilot study of Dance for Parkinson's-a community-based program that is growing in popularity-in order to compare effect sizes across multiple outcomes and to inform selection of primary and secondary outcomes for a larger trial. Study participants were people with PD who self-enrolled in either Dance for Parkinson's classes (intervention group, N=8) or PD support groups (control group, N=7). Assessments of motor function (Timed-Up-and-Go, Gait Speed, Standing Balance Test), cognitive function (Test of Everyday Attention, Verbal Fluency, Alternate Uses, Digit Span Forward and Backward), and emotion/QOL (Geriatric Depression Scale, Falls Efficacy Scale-International, Parkinson's Disease Questionnaire-39 (total score and Activities of Daily Living subscale)) were performed in both groups at baseline and follow-up. Standardized effect sizes were calculated within each group and between groups for all 12 measures. Effect sizes were positive (suggesting improvement) for all 12 measures within the intervention group and 7 of 12 measures within the control group. The largest between-group differences were observed for the Test of Everyday Attention (a measure of cognitive switching), gait speed and falls efficacy. Our findings suggest that dance has potential to improve multiple outcomes in people with PD. Future trials should consider co-primary outcomes given potential benefits in motor, cognitive and emotion/QOL domains.
帕金森病（PD）是一种进行性神经退行性疾病，与运动、认知以及情绪/生活质量（QOL）等方面的功能缺陷相关，但大多数药物和行为干预仅关注运动功能。我们的目标是对“帕金森舞蹈”进行一项试点研究——这是一个在社区中越来越受欢迎的项目——以便比较多个结果的效应大小，并为一项更大规模试验的主要和次要结果的选择提供参考。研究参与者是那些自行报名参加“帕金森舞蹈”课程（干预组，N = 8）或帕金森病支持小组（对照组，N = 7）的帕金森病患者。在基线和随访时，对两组患者进行了运动功能评估（计时起立行走测试、步速、站立平衡测试）、认知功能评估（日常注意力测试、言语流畅性、变通使用、数字顺背和倒背）以及情绪/生活质量评估（老年抑郁量表、国际跌倒效能量表、帕金森病问卷 - 39（总分及日常生活活动分量表））。对所有12项测量指标计算了每组内以及两组之间的标准化效应大小。干预组内所有12项测量指标的效应大小均为正值（表明有所改善），对照组内12项测量指标中有7项为正值。在日常注意力测试（一种认知转换测量指标）、步速和跌倒效能方面观察到最大的组间差异。我们的研究结果表明，舞蹈有可能改善帕金森病患者的多个方面。鉴于在运动、认知和情绪/生活质量领域的潜在益处，未来的试验应考虑采用共同主要结果。
