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缺血预处理与靶向再灌注损伤:30年的探索之旅

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery.

作者信息

Hausenloy Derek J, Barrabes Jose A, Bøtker Hans Erik, Davidson Sean M, Di Lisa Fabio, Downey James, Engstrom Thomas, Ferdinandy Péter, Carbrera-Fuentes Hector A, Heusch Gerd, Ibanez Borja, Iliodromitis Efstathios K, Inserte Javier, Jennings Robert, Kalia Neena, Kharbanda Rajesh, Lecour Sandrine, Marber Michael, Miura Tetsuji, Ovize Michel, Perez-Pinzon Miguel A, Piper Hans Michael, Przyklenk Karin, Schmidt Michael Rahbek, Redington Andrew, Ruiz-Meana Marisol, Vilahur Gemma, Vinten-Johansen Jakob, Yellon Derek M, Garcia-Dorado David

机构信息

The Hatter Cardiovascular Institute, University College London, London, UK.

The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK.

出版信息

Basic Res Cardiol. 2016 Nov;111(6):70. doi: 10.1007/s00395-016-0588-8. Epub 2016 Oct 20.

Abstract

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. This article provides an overview of the major topics discussed at this special meeting and underscores the huge importance and impact, the discovery of IPC has made in the field of cardiovascular research.

摘要

为纪念缺血预处理(IPC)诞生30周年这一吉祥时刻,心脏保护领域的杰出先驱们于2016年5月齐聚巴塞罗那,回顾并讨论了IPC的历史、其向缺血后处理(IPost)和远程缺血预处理(RIC)的演变、作为治疗靶点的心肌再灌注损伤,以及心脏保护的未来靶点和策略。本文概述了此次特别会议讨论的主要议题,并强调了IPC的发现对心血管研究领域产生的巨大重要性和影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2c5/5073120/13cda6eb580f/395_2016_588_Fig1_HTML.jpg

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