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陈年大蒜提取物通过改变血小板的功能特性来抑制血小板聚集。

Aged garlic extract suppresses platelet aggregation by changing the functional property of platelets.

作者信息

Morihara Naoaki, Hino Atsuko

机构信息

Drug Discovery Laboratory, Wakunaga Pharmaceutical Co. Ltd., 1624 Shimokotachi, Kodacho, Akitakata, Hiroshima, 739-1195, Japan.

Healthcare Research and Development Division, Wakunaga Pharmaceutical Co. Ltd., 1624 Shimokotachi, Kodacho, Akitakata, Hiroshima, 739-1195, Japan.

出版信息

J Nat Med. 2017 Jan;71(1):249-256. doi: 10.1007/s11418-016-1055-4. Epub 2016 Oct 20.

DOI:10.1007/s11418-016-1055-4
PMID:27766480
Abstract

Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect of AGE on the functional property of platelet by administering AGE to rats and evaluating the platelet aggregation in response to collagen in vitro. We found that AGE treatment significantly reduced the ability of platelet to aggregate and this effect of AGE was manifested on the 14 day, but not 7 day of treatment. In addition, AGE treatment produced platelets that responded to collagen by significantly increasing the amount of both the extracellular ATP and the extra- and intracellular TXB. AGE treatment also dose-dependently suppressed the phosphorylation of collagen-induced ERK, p38 and JNK. However, AGE administration did not affect the bleeding time. These findings suggest that AGE treatment results in suppression of platelet aggregation by changing the functional property of platelets to respond to collagen.

摘要

陈年大蒜提取物（AGE）是一种富含水溶性半胱氨酰部分的大蒜制剂，据报道对心血管疾病有多种有益作用，包括抑制血小板聚集。然而，AGE对血小板的作用方式尚不清楚。在本研究中，我们通过给大鼠施用AGE并在体外评估血小板对胶原蛋白的聚集反应，来研究AGE对血小板功能特性的影响。我们发现，AGE处理显著降低了血小板的聚集能力，且这种作用在处理的第14天而非第7天表现出来。此外，AGE处理产生的血小板对胶原蛋白的反应是细胞外ATP以及细胞外和细胞内TXB的量显著增加。AGE处理还剂量依赖性地抑制胶原蛋白诱导的ERK、p38和JNK的磷酸化。然而，施用AGE并不影响出血时间。这些发现表明，AGE处理通过改变血小板对胶原蛋白的反应功能特性来抑制血小板聚集。

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Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis.补充老化大蒜提取物与棕色脂肪增加、白色脂肪组织减少相关，并预示冠状动脉粥样硬化无进展。
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J Ethnopharmacol. 2013 Jan 9;145(1):162-7. doi: 10.1016/j.jep.2012.10.045. Epub 2012 Nov 2.
10
Aged garlic extract inhibits platelet activation by increasing intracellular cAMP and reducing the interaction of GPIIb/IIIa receptor with fibrinogen.大蒜素通过增加细胞内 cAMP 和减少 GPIIb/IIIa 受体与纤维蛋白原的相互作用来抑制血小板活化。
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