MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, China.
Environ Int. 2016 Dec;97:7-14. doi: 10.1016/j.envint.2016.10.008. Epub 2016 Oct 19.
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are commonly used in industrial applications and consumer products, and their potential health impacts are of concern, especially for vulnerable population like fetuses. However, in utero exposure to PFASs and health implications are far from fully characterized in China. To fill in the gap, we analyzed 10 PFASs in cord plasma samples (N=687) collected in Shanghai between 2011 and 2012, one of the regions widely polluted with PFASs in China. A questionnaire survey on maternal and diet-related factors was conducted. Except for perfluoroheptanoic acid (PFHpA) and perfluorooctane sulfonamide (PFOSA), all other PFASs were detected in ˃90% of the samples. Perfluorooctanoic acid (PFOA) was the most predominant PFAS (median value: 6.96ng/mL), followed by perfluorooctane sulfonate (PFOS) (2.48ng/mL). PFOA and PFOS combined contributed to 80% of the total PFASs. The final multiple regression models showed that maternal factors including maternal age, body mass index, gestational age, economic status and educational level as well as consumption of fish and wheat were significantly related with concentrations of PFASs in cord blood. The risk assessment using the hazard quotients (HQs) approach on the basis of plasma PFAS levels indicated no potential concern for developmental toxicity in the local newborns. The results demonstrate the unique profiles of local prenatal exposure to PFASs, suggesting that PFOA has been the primary human exposure due to its widespread use and pollution. Special attention to high PFOA exposure and confirmation of potential determinants should be taken as a priority in the future plan for risk management and actions in this area.
全氟烷基和多氟烷基物质（PFASs）广泛应用于工业应用和消费产品中，其潜在的健康影响令人关注，特别是对于胎儿等脆弱人群。然而，在中国，PFASs 的宫内暴露及其健康影响远未得到充分描述。为了填补这一空白，我们分析了 2011 年至 2012 年期间在上海采集的 687 例脐带血浆样本中的 10 种 PFASs，上海是中国 PFASs 广泛污染的地区之一。对母亲和饮食相关因素进行了问卷调查。除了全氟庚酸（PFHpA）和全氟辛烷磺酰胺（PFOSA）外，所有其他 PFASs 在 ˃90%的样本中均有检出。全氟辛酸（PFOA）是最主要的 PFAS（中位数：6.96ng/mL），其次是全氟辛烷磺酸（PFOS）（2.48ng/mL）。PFOA 和 PFOS 合计占总 PFASs 的 80%。最终的多元回归模型显示，母亲的年龄、体重指数、妊娠周数、经济状况和受教育程度以及鱼类和小麦的消费等因素与脐带血中 PFASs 的浓度显著相关。基于血浆 PFAS 水平采用危害商（HQs）方法进行的风险评估表明，当地新生儿没有发育毒性的潜在担忧。结果表明，当地产前暴露于 PFASs 的情况具有独特的特征，这表明由于其广泛的使用和污染，PFOA 已成为主要的人类暴露因素。在该地区未来的风险管理和行动规划中，应优先考虑高 PFOA 暴露和潜在决定因素的确认。
