Song Jun-Long, Chen Chuang, Yuan Jing-Ping, Sun Sheng-Rong
Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Cancer Med. 2016 Dec;5(12):3475-3488. doi: 10.1002/cam4.943. Epub 2016 Oct 24.
Breast cancer is currently the most common form of cancer and the second-leading cause of death from cancer in women. Though considerable progress has been made in the treatment of breast cancer, the heterogeneity of tumors (both inter- and intratumor) remains a considerable diagnostic and prognostic challenge. From clinical observation to genetic mutations, the history of understanding the heterogeneity of breast cancer is lengthy and detailed. Effectively detecting heterogeneity in breast cancer is important during treatment. Various methods of depicting this heterogeneity are now available and include genetic, pathologic, and imaging analysis. These methods allow characterization of the heterogeneity of breast cancer on a genetic level, providing greater insight during the process of establishing an effective therapeutic plan. This study reviews how the understanding of tumor heterogeneity in breast cancer evolved, and further summarizes recent advances in the detection and monitoring of this heterogeneity in patients with breast cancer.
乳腺癌是目前最常见的癌症形式，也是女性癌症死亡的第二大原因。尽管在乳腺癌治疗方面已取得了相当大的进展，但肿瘤的异质性（包括肿瘤间和肿瘤内）仍然是一个相当大的诊断和预后挑战。从临床观察到基因突变，了解乳腺癌异质性的历史漫长而详细。在治疗过程中，有效检测乳腺癌的异质性很重要。现在有各种描述这种异质性的方法，包括基因、病理和影像分析。这些方法能够在基因水平上对乳腺癌的异质性进行表征，从而在制定有效治疗方案的过程中提供更深入的见解。本研究回顾了对乳腺癌肿瘤异质性的认识是如何演变的，并进一步总结了乳腺癌患者中这种异质性检测和监测的最新进展。
