Chang Ye, Li Yuan, Guo Xiaofan, Dai Dongxue, Sun Yingxian
Department of Cardiology, the First Hospital of China Medical University, Shenyang 110001, China.
Int J Environ Res Public Health. 2016 Oct 19;13(10):1027. doi: 10.3390/ijerph13101027.
In 2010, the American Heart Association has proposed a new concept "ideal cardiovascular health" (CVH) based on seven CVH metrics: smoking, body mass index, physical activity, diet score, total cholesterol, blood pressure, and fasting plasma glucose. We aimed to determine the association of CVH with atherogenic index of plasma (AIP), a strong marker for atherosclerosis (AS). This cross-sectional study was conducted in the rural areas of northeast China and 11,113 middle-aged subjects were enrolled. Seven CVH metrics were classified into ideal, intermediate, and poor groups. AIP was calculated as log (TG/HDL) (triglycerides/high-density lipoprotein cholesterol). AIP > 0.21 was classified into the high AIP group and served as dependent variable. All seven CVH metrics were correlated with AIP. A gradient relationship between the number of poor CVH metrics and the prevalence of high AIP existed. Log binomial regression analysis showed that compared to those with five to seven ideal CVH metrics, individuals with four, three, two, one, and no ideal CVH metrics had 1.67, 2.66, 4.00, 5.30 and 6.50 times higher prevalence for high AIP. The subjects with poor CVH status had 2.73 times higher prevalence for high AIP. We found an inversely gradient relationship between the number of ideal CVH metrics and lower prevalence of high AIP.
2010年,美国心脏协会基于七个心血管健康(CVH)指标提出了一个新的概念“理想心血管健康”:吸烟、体重指数、身体活动、饮食评分、总胆固醇、血压和空腹血糖。我们旨在确定心血管健康与血浆致动脉粥样硬化指数(AIP)之间的关联,AIP是动脉粥样硬化(AS)的一个重要标志物。这项横断面研究在中国东北地区农村地区开展,纳入了11113名中年受试者。七个心血管健康指标被分为理想、中等和差三组。AIP计算公式为log(甘油三酯/高密度脂蛋白)(甘油三酯/高密度脂蛋白胆固醇)。AIP>0.21被归为高AIP组,并作为因变量。所有七个心血管健康指标均与AIP相关。心血管健康差的指标数量与高AIP患病率之间存在梯度关系。对数二项回归分析显示,与具有五到七个理想心血管健康指标的人相比,具有四个、三个、两个、一个和没有理想心血管健康指标的个体高AIP患病率分别高1.67倍、2.66倍、4.00倍、5.30倍和6.50倍。心血管健康状况差的受试者高AIP患病率高2.73倍。我们发现理想心血管健康指标数量与高AIP较低患病率之间存在反向梯度关系。