伊朗东南部扎黑丹医科大学学生肥胖指数与血脂异常的关系
Obesity Indices in relation to Lipid Abnormalities among Medical University Students in Zahedan, South-East of Iran.
作者信息
Eslami Omid, Shahraki Mansour, Shahraki Touran
机构信息
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, Faculty of Medicine and Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Int J Prev Med. 2019 Feb 12;10:15. doi: 10.4103/ijpvm.IJPVM_177_17. eCollection 2019.
BACKGROUND
There is no statement on the ability of obesity indices in prediction of lipid abnormalities among young adults. The present study was conducted to determine the ability of obesity indices as predictors of lipid abnormalities among a group of young adults.
MATERIALS AND METHODS
A total of 353 medical university students aged 18-25 years (188 males and 165 females) participated in this cross-sectional study in 2014. Weight, height, waist circumference (WC), and hip circumference were measured to calculate obesity indices including body mass index (BMI), waist-to-hip ratio, and waist-to-height ratio (WHtR). Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured by commercially available kits and were applied to calculate low-density lipoprotein cholesterol (LDL-C) and atherogenic parameters including LDL-C/ HDL-C ratio, TC/HDL-C ratio, non-HDL-C, and atherogenic index of plasma (AIP).
RESULTS
Subjects with BMI ≥25 kg/m had a greater value of all lipid profiles and atherogenic parameters ( < 0.05) except for HDL-C ( > 0.05) compared to subjects with BMI <25 kg/m. In logistic regression model, BMI ≥25 kg/m was significantly associated with the highest odds for elevated TC (odds ratio [OR] = 7.67, = 0.003), LDL-C (OR = 3.24, = 0.01), TC:HDL-C (OR = 4.98, = 0.01), and non-HDL-C(OR = 4.32, = 0.001) in males, as well as high values of TG (OR = 8.80, = 0.002), LDL-C:HDL-C (OR = 3.64, = 0.01), and AIP (OR = 9.65, < 0.001) in females. In terms of central obesity indices, males with WC ≥102 cm and females with WC ≥88 cm had the highest odds of increased LDL-C:HDL-C (OR = 6.71, = 0.01) and TC:HDL-C (OR = 3.25, = 0.050), respectively. In addition, females with WHtR ≥0.50 had the highest odds of high TC (OR = 3.56, = 0.02) and non-HDL-C (OR = 2.70, = 0.02).
CONCLUSIONS
Overall, the findings of the present study showed that BMI was a stronger index for prediction of classical lipid parameters and atherogenic parameters than central obesity indices in medical students.
背景
目前尚无关于肥胖指数预测年轻成年人脂质异常能力的相关论述。本研究旨在确定肥胖指数作为一组年轻成年人脂质异常预测指标的能力。
材料与方法
2014年，共有353名年龄在18 - 25岁的医科大学生（188名男性和165名女性）参与了这项横断面研究。测量体重、身高、腰围（WC）和臀围，以计算肥胖指数，包括体重指数（BMI）、腰臀比和腰高比（WHtR）。采用市售试剂盒测定血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL - C）和甘油三酯（TG），并用于计算低密度脂蛋白胆固醇（LDL - C）以及动脉粥样硬化参数，包括LDL - C/HDL - C比值、TC/HDL - C比值、非HDL - C和血浆动脉粥样硬化指数（AIP）。
结果
与BMI <25 kg/m的受试者相比，BMI≥25 kg/m的受试者除HDL - C外（P>0.05），所有血脂谱和动脉粥样硬化参数的值均更高（P<0.05）。在逻辑回归模型中，BMI≥25 kg/m与男性TC升高的最高比值比（优势比[OR]=7.67，P = 0.003）、LDL - C（OR = 3.24，P = 0.01）、TC:HDL - C（OR = 4.98，P = 0.01）和非HDL - C（OR = 4.32，P = 0.001）显著相关，与女性TG升高（OR = 8.80，P = 0.002）以及LDL - C:HDL - C（OR = 3.64，P = 0.01）和AIP（OR = 9.65，P<0.001）显著相关。就中心性肥胖指数而言，WC≥102 cm的男性和WC≥88 cm的女性LDL - C:HDL - C升高的几率最高（OR = 6.71，P = 0.01）和TC:HDL - C升高的几率最高（OR = 3.25，P = 0.050）。此外，WHtR≥0.50的女性TC升高（OR = 3.56，P = 0.02）及非HDL - C升高（OR = 2.70，P = 0.02）的几率最高。
结论
总体而言，本研究结果表明，在医科学生中，BMI比中心性肥胖指数更能有效预测经典脂质参数和动脉粥样硬化参数。
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