Sherr L, Molloy A, Macedo A, Croome N, Johnson M A
University College London , UK.
Royal Free London NHS Foundation Trust , London , UK.
J Virus Erad. 2016 Oct 5;2(4):215-218. doi: 10.1016/S2055-6640(20)30874-8.
Treatment rollout has dramatically improved life expectancy for people with HIV and AIDS. Women represent a substantial proportion of patients in the UK (approximately one-third of patients in care are female according to the HIV Annual Report 2014). This study examines psychosocial and biomedical issues for women diagnosed with HIV in the UK, comparing those above and below 45 years of age to examine menopause and ageing issues.
Consecutive clinic attenders in a large outpatient London HIV clinic were invited to participate in the study. Data were available for 170 (68%) women. In 57 women above the age of 45 data were available regarding menopause detailed insights.
Compared with women aged under 45, women >45 years old were significantly less likely to be in a relationship (=0.01), had higher anxiety scores (=0.002), more likely to be classified as moderate to severe (25.9% 9.1%; χ=6.1, =0.01). There were no differences in terms of suicidal ideation, which was high for both groups of women (56.6%). Older women had higher psychological symptoms on the MSAS scale form and significantly higher PHQ-9 depression levels. A higher proportion of older women scored above the cut-off point for moderate to severe depression (9.2% 21.8%; χ=3.7, =0.048). Fewer older women had no mental health challenges (26.1% 42.4%) and more had multiple comorbidities (=0.07).
The vast majority of women reported experiencing a variety of physical and psychological menopause-related symptoms and there was a high suicide ideation rate in both groups of women. Over half of the group of menopausal women recorded distressing symptoms such as hot flushes, sweating, decreased sexual desire, back pain, night sweats, avoiding intimacy, involuntary urination and skin changes, yet few sought help. Age-specific, psychosexual and menopause services should be routinely available for women with HIV.
治疗的推广显著提高了艾滋病毒感染者和艾滋病患者的预期寿命。在英国,女性占患者的很大比例(根据《2014年艾滋病毒年度报告》,接受治疗的患者中约三分之一为女性)。本研究调查了英国被诊断感染艾滋病毒的女性的心理社会和生物医学问题,比较了45岁及以上和45岁以下的女性,以研究更年期和衰老问题。
邀请伦敦一家大型门诊艾滋病毒诊所的连续就诊者参与研究。共有170名(68%)女性的数据可供分析。在57名45岁以上的女性中,有关于更年期的详细见解的数据。
与45岁以下的女性相比,45岁及以上的女性处于恋爱关系中的可能性显著更低(P=0.01),焦虑得分更高(P=0.002),更有可能被归类为中度至重度(25.9%对9.1%;χ²=6.1,P=0.01)。两组女性的自杀意念方面没有差异,两组女性的自杀意念发生率都很高(56.6%)。老年女性在MSAS量表上的心理症状更严重,PHQ-9抑郁水平显著更高。更高比例的老年女性得分高于中度至重度抑郁的临界点(9.2%对21.8%;χ²=3.7,P=0.048)。没有心理健康问题的老年女性更少(26.1%对42.4%),有多种合并症的更多(P=0.07)。
绝大多数女性报告经历了各种与更年期相关的身体和心理症状,两组女性的自杀意念发生率都很高。超过一半的更年期女性记录了潮热、出汗、性欲下降、背痛、盗汗、避免亲密接触、尿失禁和皮肤变化等令人苦恼的症状,但很少有人寻求帮助。应为感染艾滋病毒的女性常规提供针对性别的、性心理和更年期服务。