Piao Xiang Lan, Yoo Hye Hyun, Kim Hyun Young, Kang Tak Lim, Hwang Gwi Seo, Park Jeong Hill
School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Arch Pharm Res. 2006 Sep;29(9):741-5. doi: 10.1007/BF02974073.
In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 microg/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.
在我们寻找治疗更年期症状的新型植物雌激素的过程中，从白芷中分离出了11种呋喃香豆素，并在石川细胞系上测试了它们的雌激素活性。在所测试的化合物中，9-羟基-4-甲氧基补骨脂素和异欧前胡素表现出很强的诱导碱性磷酸酶（AP）的能力，其半数有效浓度（EC50）值分别为1.1和0.8微克/毫升，而其他9种呋喃香豆素活性较弱或仅有轻微活性。
