类风湿关节炎中的淋巴细胞减少症。
Lymphopenia in rheumatoid arthritis.
作者信息
Symmons D P, Farr M, Salmon M, Bacon P A
机构信息
Rheumatism Research Wing, Medical School, University of Birmingham.
出版信息
J R Soc Med. 1989 Aug;82(8):462-3. doi: 10.1177/014107688908200806.
Abstract
Lymphopenia is a recognized but poorly studied feature of rheumatoid arthritis (RA). We set out to establish the prevalence and significance of lymphopenia in RA. A group of 66 RA patients was studied for one year. During this time 10 (15%) had persistent lymphopenia (lymphocyte count less than 1.00 X 10(9)/l) without evidence of Felty's syndrome. A separate study of lymphocyte subsets in 13 lymphopenic RA patients showed marked reduction in T-cell numbers with normal circulating B-cell numbers. The numbers of CD4 and CD8 positive T-cells were equally depressed. Lymphopenia may indicate more severe disease. It was not influenced by changes in disease activity or therapy.
摘要
淋巴细胞减少是类风湿关节炎（RA）的一个已被认识但研究较少的特征。我们着手确定RA中淋巴细胞减少的患病率及其意义。对一组66例RA患者进行了为期一年的研究。在此期间，10例（15%）患者存在持续性淋巴细胞减少（淋巴细胞计数低于1.00×10⁹/L），且无费尔蒂综合征的证据。对13例淋巴细胞减少的RA患者的淋巴细胞亚群进行的另一项研究显示，T细胞数量显著减少，而循环B细胞数量正常。CD4和CD8阳性T细胞数量均下降。淋巴细胞减少可能表明疾病更为严重。它不受疾病活动度或治疗变化的影响。
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