类风湿性关节炎患者外周血中携带转铁蛋白受体的细胞。
Transferrin receptor bearing cells in the peripheral blood of patients with rheumatoid arthritis.
作者信息
Salmon M, Bacon P A, Symmons D P, Blann A D
出版信息
Clin Exp Immunol. 1985 Nov;62(2):346-52.
Abstract
Activated, proliferating lymphocytes are a feature of rheumatoid arthritis. They are present both in the synovial membrane and in the peripheral circulation. The expression of transferrin receptors(TFR) is a good marker of cellular proliferation. This study shows increased levels of circulating TFR-bearing lymphocytes in patients with rheumatoid arthritis (RA). The TFR+ population contains a disproportionately large number of T4+ cells, leading to a high T4:T8 ratio (5:1 in the TFR+ population, compared to 2:1 in the total circulating pool of lymphocytes). This reflects the pattern found in the rheumatoid synovium and suggests that lymphocyte activation in RA may be an extra-articular phenomenon. The TFR+ population also contains a range of non-T cells, including B cells, and a population bearing phenotypic similarities to natural killer (NK) cells.
摘要
活化、增殖的淋巴细胞是类风湿性关节炎的一个特征。它们存在于滑膜和外周循环中。转铁蛋白受体（TFR）的表达是细胞增殖的一个良好标志物。这项研究表明，类风湿性关节炎（RA）患者循环中携带TFR的淋巴细胞水平升高。TFR+群体中T4+细胞的数量不成比例地多，导致T4:T8比值较高（TFR+群体中为5:1，而淋巴细胞总循环库中为2:1）。这反映了类风湿滑膜中发现的模式，并表明RA中的淋巴细胞活化可能是一种关节外现象。TFR+群体还包含一系列非T细胞，包括B细胞，以及一群在表型上与自然杀伤（NK）细胞相似的细胞。
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本文引用的文献
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