Brown Michael N, Shiple Brian J, Scarpone Michael
1515, 116th Avenue NE, Suite #202, Bellevue, WA 98004, USA; 10 Harris Court, Building A, Suite 1, Monterey, CA 93940, USA.
1788 Wilmington Pike, Suite 2000, Glenn Mills, PA 19342, USA.
Phys Med Rehabil Clin N Am. 2016 Nov;27(4):941-984. doi: 10.1016/j.pmr.2016.07.003.
Tendon and ligament injuries and degenerative conditions of these soft tissues have poor healing potential and healing is often incomplete. Biocellular and orthobiologic approaches including PRP and stem cell therapies are reviewed. A review of some of the regenerative medicine science and difficulties facing physicians exploring these methods is presented. A series of cases are reviewed demonstrating the application of these principles. Clinical experience with many of these biocellular interventions is outpacing validation in basic science studies. Clinical experience dictates the need for repeated clinical and imaging evaluation and the need for repeated intervention or change in strategies when needed.
肌腱和韧带损伤以及这些软组织的退行性疾病愈合潜力差，且愈合往往不完全。本文综述了包括富血小板血浆（PRP）和干细胞疗法在内的生物细胞和 orthobiologic 方法。介绍了一些再生医学科学以及探索这些方法的医生所面临的困难。回顾了一系列病例以证明这些原则的应用。许多这些生物细胞干预措施的临床经验超过了基础科学研究中的验证。临床经验表明需要进行反复的临床和影像学评估，以及在需要时进行反复干预或改变策略。
