Walters Russel M, Anim-Danso Emmanuel, Amato Stephanie M, Capone Kimberly A, Mack M Catherine, Telofski Lorena S, Mays David A
Skin Care Research & Development, Johnson & Johnson Consumer Inc., Skillman, NJ, USA.
Clin Cosmet Investig Dermatol. 2016 Oct 11;9:339-345. doi: 10.2147/CCID.S111729. eCollection 2016.
Hard water is associated with atopic dermatitis (eczema). We wanted to determine if a baby cleanser and its individual components altered free ionized calcium (Ca) in a simulated hard water baby bath. For these studies, an in vitro determination of free Ca in a simulated hard water baby bath, and an in vivo exploratory study of free Ca absorption into skin from hard water were performed.
Free Ca was measured with an ion-sensitive electrode in vitro in hard water (100-500 ppm, Ca) before and after addition of the cleanser and/or its components. In an exploratory study, absorption of Ca into skin from hard water was determined in three female participants (aged 21-29 years).
At an in-use dilution of 1%, the test cleanser reduced free Ca from ~500 ppm to <200 ppm; a 10% in-use dilution bound virtually all free Ca. The anionic surfactant component contributed the most to this effect. In the exploratory in vivo study, we measured a reduction of ~15% in free Ca from simulated hard water over 10 minutes.
Baby cleansers can bind free Ca and reduce the effective water hardness of bath water. Reducing the amount of free Ca in the water will reduce the availability of the ion for binding to the skin. Altering or reducing free Ca concentrations in bath water may be an important parameter in creating the ideal baby bath.
硬水与特应性皮炎(湿疹)有关。我们想确定一款婴儿沐浴露及其各个成分是否会改变模拟硬水婴儿浴中的游离离子钙(Ca)。对于这些研究,我们进行了模拟硬水婴儿浴中游离钙的体外测定,以及硬水中游离钙经皮肤吸收的体内探索性研究。
在添加沐浴露及其成分之前和之后,使用离子敏感电极在体外测量硬水(100 - 500 ppm,Ca)中的游离钙。在一项探索性研究中,测定了三名女性参与者(年龄21 - 29岁)从硬水中吸收钙进入皮肤的情况。
在使用浓度为1%时,测试沐浴露将游离钙从约500 ppm降低至<200 ppm;使用浓度为10%时几乎结合了所有游离钙。阴离子表面活性剂成分对此效果贡献最大。在探索性体内研究中,我们测量到在10分钟内模拟硬水中的游离钙减少了约15%。
婴儿沐浴露可以结合游离钙并降低浴水的有效水硬度。减少水中游离钙的量会降低离子与皮肤结合的可用性。改变或降低浴水中游离钙的浓度可能是打造理想婴儿浴的一个重要参数。