纳米二次离子质谱成像：一种用于可视化和定量细胞及组织中脂质的方法。
NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues.
作者信息
He Cuiwen, Fong Loren G, Young Stephen G, Jiang Haibo
机构信息
Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Departments of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
出版信息
J Investig Med. 2017 Mar;65(3):669-672. doi: 10.1136/jim-2016-000239. Epub 2016 Oct 28.
Abstract
Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity.
摘要
在过去几十年里，已经采用了几种方法对细胞和组织中的脂质进行成像，但大多数方法的空间分辨率和灵敏度都有限。在此，我们讨论一种相对较新的方法——纳米级二次离子质谱成像，它能够以定量方式、高空间分辨率和高灵敏度对细胞和组织中的脂质进行可视化。
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