Shaka Mohammed Feyisso, Hussen Kabthymer Robel, Meshesha Meiraf Daniel, Borde Moges Tadesse
Dilla University, College of Health Sciences and Medicine, School of Public Health, Dilla, Ethiopia.
Dilla University, College of Health Sciences and Medicine, School of Medicine, Dilla, Ethiopia.
Ann Med Surg (Lond). 2022 Feb 24;75:103403. doi: 10.1016/j.amsu.2022.103403. eCollection 2022 Mar.
Studies show that 25 (OH) D status appears to have beneficial influence on the incidence and severity of some types of infections. However, studies with vitamin D supplementation on young children produced conflicting results. This study was conducted to assess and compare the pooled prevalence of vitamin D deficiency among healthy and sick children in sub-Saharan Africa.
A systematic review of PubMed, CINAHL, Web of science, global health and Google scholar electronic databases was conducted. Both published and unpublished observational studies conducted among under-five children in the year 2010-2020 were included. STATA Version 14 was used for analysis. Heterogeneity of studies was assessed using I test. A random-effects model was used to estimate the pooled prevalence among both healthy and sick children.
A total of 1212 articles were retrieved from data bases, of which 10 papers were included. The pooled prevalence of vitamin D deficiency among healthy children was 50.06% with mean serum vitamin D level of 41.06 nm/L. The pooled prevalence among the sick children was 39.36% with 66.96 nm/L of mean concentration. The pooled prevalence among healthy children was significantly higher compared to those who have common medical illnesses and the pooled mean concentration among the sick was also much higher than the mean concentration among healthy children.
The pooled prevalence among both groups of population was significantly high and a concerning public health problem. The prevalence among healthy children was much higher as compared to sick children.
研究表明，25（OH）D状态似乎对某些类型感染的发生率和严重程度有有益影响。然而，关于补充维生素D对幼儿影响的研究结果相互矛盾。本研究旨在评估和比较撒哈拉以南非洲健康儿童和患病儿童中维生素D缺乏的合并患病率。
对PubMed、CINAHL、科学网、全球健康和谷歌学术电子数据库进行系统综述。纳入2010 - 2020年期间对五岁以下儿童进行的已发表和未发表的观察性研究。使用STATA 14版进行分析。使用I检验评估研究的异质性。采用随机效应模型估计健康儿童和患病儿童中的合并患病率。
从数据库中检索到共1212篇文章，其中10篇被纳入。健康儿童中维生素D缺乏的合并患病率为50.06%，血清维生素D平均水平为41.06 nmol/L。患病儿童中的合并患病率为39.36%，平均浓度为66.96 nmol/L。与患有常见疾病的儿童相比，健康儿童中的合并患病率显著更高，患病儿童的合并平均浓度也远高于健康儿童中的平均浓度。
两组人群中的合并患病率都显著较高，是一个令人担忧的公共卫生问题。与患病儿童相比，健康儿童中的患病率更高。
