暴露于镉的地中海贻贝三个生命阶段的差异代谢反应。

Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium.

作者信息

Wu Huifeng, Xu Lanlan, Yu Deliang, Ji Chenglong

机构信息

Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, YICCAS, Yantai, 264003, P. R. China.

University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.

出版信息

Ecotoxicology. 2017 Jan;26(1):74-80. doi: 10.1007/s10646-016-1741-8. Epub 2016 Oct 28.

DOI:10.1007/s10646-016-1741-8

PMID:27796687

Abstract

Cadmium (Cd) is one of the most important metal contaminants in the Bohai Sea. In this work, NMR-based metabolomics was used to investigate the toxicological effects of Cd at an environmentally relevant concentration (50 µg L) in three different life stages (D-shape larval, juvenile and adult) of mussels Mytilus galloprovincialis. Results indicated that the D-shape larval mussel was the most sensitive life stage to Cd. The significantly different metabolic profiles meant that Cd induced differential toxicological effects in three life stages of mussels. Basically, Cd caused osmotic stress in all the three life stages via different metabolic pathways. Cd exposure reduced the anaerobiosis in D-shape larval mussels and disturbed lipid metabolism in juvenile mussels, respectively. Compared with the D-shape larval and juvenile mussels, the adult mussels reduced energy consumption to deal with Cd stress.

摘要

镉（Cd）是渤海最重要的金属污染物之一。在本研究中，基于核磁共振的代谢组学被用于研究镉在环境相关浓度（50微克/升）下对三种不同生活阶段（D形幼虫、幼体和成体）的加利福尼亚贻贝（Mytilus galloprovincialis）的毒理学影响。结果表明，D形幼虫期贻贝是对镉最敏感的生活阶段。显著不同的代谢谱意味着镉在贻贝的三个生活阶段诱导了不同的毒理学效应。基本上，镉通过不同的代谢途径在所有三个生活阶段都引起了渗透胁迫。镉暴露分别降低了D形幼虫期贻贝的无氧代谢，并扰乱了幼体贻贝的脂质代谢。与D形幼虫期和幼体贻贝相比，成体贻贝通过减少能量消耗来应对镉胁迫。