Schiavi Costantino, Tassi Filippo, Finzi Alessandro, Strobbe Ernesto, Cellini Mauro
Department of Experimental, Diagnostic, and Specialty Medicine, Ophthalmology Service, University of Bologna, Bologna, Italy.
Clin Ophthalmol. 2016 Oct 19;10:2061-2068. doi: 10.2147/OPTH.S117803. eCollection 2016.
Steady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes.
Fifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisometropic amblyopia (mean 28.7±5.9 years) were analyzed using steady-state PERG and FDT.
The amplitude of steady-state PERG was significantly different not only among the control group and both the amblyopic eye (=0.0001) and the sound eye group (=0.0001), but also between the latter two groups (=0.006). The difference in FDT mean deviation was statistically significant not only between the control group and amblyopic eye group (=0.0002), but also between the control group and the sound eye group (=0.0009). The FDT pattern standard deviation was significantly higher in the control group rather than in the amblyopic eye (=0.0001) or the sound eye group (=0.0001). A correlation was found between the reduction in PERG amplitude and the increase in FDT-pattern standard deviation index not only in amblyopic (=0.0025) and sound (=0.0023) eyes, but also in the healthy control group (=0.0001).
These data demonstrate that in anisometropic amblyopia, there is an abnormal functionality of a subgroup of the magnocellular ganglion cells (M-Y), and the involvement of these cells, together with the parvocellular pathway, may play a key role in the clinical expression of the disease.
稳态图形视网膜电图（PERG）和频率加倍技术（FDT）视野检查可用于选择性研究成年屈光参差性弱视患者中M-Y神经节细胞的活性。
使用稳态PERG和FDT对15名正常受试者（平均年龄27.8±4.1岁）和15名成年屈光参差性弱视患者（平均年龄28.7±5.9岁）进行分析。
稳态PERG的振幅不仅在对照组与弱视眼组（=0.0001）和健眼组（=0.0001）之间存在显著差异，而且在弱视眼组和健眼组之间也存在显著差异（=0.006）。FDT平均偏差的差异不仅在对照组与弱视眼组之间具有统计学意义（=0.0002），而且在对照组与健眼组之间也具有统计学意义（=0.0009）。对照组的FDT图形标准差显著高于弱视眼组（=0.0001）或健眼组（=0.0001）。不仅在弱视眼（=0.0025）和健眼（=0.0023）中，而且在健康对照组中（=0.0001），均发现PERG振幅降低与FDT图形标准差指数增加之间存在相关性。
这些数据表明，在屈光参差性弱视中，大细胞神经节细胞（M-Y）的一个亚组存在功能异常，这些细胞与小细胞通路的共同参与可能在该疾病的临床表现中起关键作用。
