• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于区分健康眼和青光眼眼的图形视网膜电图和视功能心理物理学测试。

Pattern electroretinogram and psychophysical tests of visual function for discriminating between healthy and glaucoma eyes.

机构信息

Hamilton Glaucoma Center and Department of Ophthalmology, University of California at San Diego, La Jolla, California 92093-0946, USA.

出版信息

Am J Ophthalmol. 2010 Mar;149(3):488-95. doi: 10.1016/j.ajo.2009.09.027.

DOI:10.1016/j.ajo.2009.09.027
PMID:20172073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2827352/
Abstract

PURPOSE

To compare the diagnostic accuracy of the pattern electroretinogram (pattern ERG) to that of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), and frequency-doubling technology (FDT) perimetry for discriminating between healthy and glaucomatous eyes.

DESIGN

Cross-sectional study.

METHODS

Eighty-three eyes of 42 healthy recruits and 92 eyes of 54 glaucoma patients (based on optic disc appearance) from the University of California, San Diego, Diagnostic Innovations in Glaucoma Study were tested with pattern ERG for glaucoma detection (PERGLA; Lace Elettronica, Pisa, Italy), SAP, SWAP, and FDT within 9 months. Receiver operating characteristic (ROC) curves were generated and compared for pattern ERG amplitude and SAP, SWAP, and FDT mean deviation and pattern standard deviation (PSD). Sensitivities and specificities were compared and agreement among tests was described.

RESULTS

The area under the ROC curve for pattern ERG amplitude was 0.744 (95% confidence interval = 0.670, 0.818). The ROC curve area was 0.786 (0.720, 0.853) for SAP PSD, 0.732 (0.659, 0.806) for SWAP PSD, and 0.818 (0.758, 0.879) for FDT PSD. At 95% specificity, sensitivities of SAP and FDT PSD were significantly higher than that of pattern ERG amplitude; at 80% specificity, similar sensitivities were observed among tests. Agreement among tests was slight to moderate.

CONCLUSION

The diagnostic accuracy of the pattern ERG amplitude was similar to that of SAP and SWAP, but somewhat worse than that of FDT. Nevertheless, the pattern ERG may hold some advantage over psychophysical testing because of its largely objective nature.

摘要

目的

比较图形视网膜电图（图形 ERG）与标准自动视野计（SAP）、短波长自动视野计（SWAP）和频域倍增技术（FDT）在鉴别健康眼与青光眼眼中的诊断准确性。

设计

横断面研究。

方法

对来自加利福尼亚大学圣地亚哥分校诊断性青光眼创新研究的 42 名健康应征者的 83 只眼和 54 名青光眼患者（根据视盘外观）进行图形 ERG 检查以进行青光眼检测（PERGLA；意大利比萨 Lace Elettronica），在 9 个月内进行 SAP、SWAP 和 FDT 检查。生成并比较了图形 ERG 振幅和 SAP、SWAP 和 FDT 平均偏差及图形标准偏差（PSD）的接收器工作特性（ROC）曲线。比较了敏感性和特异性，并描述了测试之间的一致性。

结果

图形 ERG 振幅的 ROC 曲线下面积为 0.744（95%置信区间=0.670，0.818）。SAP PSD 的 ROC 曲线下面积为 0.786（0.720，0.853），SWAP PSD 为 0.732（0.659，0.806），FDT PSD 为 0.818（0.758，0.879）。在 95%特异性下，SAP 和 FDT PSD 的敏感性显著高于图形 ERG 振幅；在 80%特异性下，各测试之间的敏感性相似。测试之间的一致性为轻度至中度。

结论

图形 ERG 振幅的诊断准确性与 SAP 和 SWAP 相似，但略逊于 FDT。尽管如此，由于其主要的客观性，图形 ERG 可能比心理物理测试具有一定的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/2827352/0ed0c33aa90b/nihms152913f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/2827352/b40ee9390d9c/nihms152913f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/2827352/f8720470e28b/nihms152913f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/2827352/0ed0c33aa90b/nihms152913f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/2827352/b40ee9390d9c/nihms152913f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/2827352/f8720470e28b/nihms152913f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9477/2827352/0ed0c33aa90b/nihms152913f3.jpg

相似文献

1
Pattern electroretinogram and psychophysical tests of visual function for discriminating between healthy and glaucoma eyes.用于区分健康眼和青光眼眼的图形视网膜电图和视功能心理物理学测试。
Am J Ophthalmol. 2010 Mar;149(3):488-95. doi: 10.1016/j.ajo.2009.09.027.
2
Diagnostic accuracy of pattern electroretinogram optimized for glaucoma detection.优化用于青光眼检测的图形视网膜电图的诊断准确性。
Ophthalmology. 2009 Mar;116(3):437-43. doi: 10.1016/j.ophtha.2008.10.026. Epub 2009 Jan 22.
3
Short wavelength automated perimetry, frequency doubling technology perimetry, and pattern electroretinography for prediction of progressive glaucomatous standard visual field defects.短波自动视野计、频率加倍技术视野计和图形视网膜电图用于预测青光眼性标准视野缺损的进展情况。
Ophthalmology. 2002 May;109(5):1009-17. doi: 10.1016/s0161-6420(02)01015-1.
4
Detection of optic neuropathy in glaucomatous eyes with normal standard visual fields using a test battery of short-wavelength automated perimetry and pattern electroretinography.使用短波长自动视野计和图形视网膜电图测试组合检测标准视野正常的青光眼性眼中的视神经病变。
Ophthalmology. 2002 Jul;109(7):1350-61. doi: 10.1016/s0161-6420(02)01100-4.
5
Diagnostic accuracy of the Matrix 24-2 and original N-30 frequency-doubling technology tests compared with standard automated perimetry.与标准自动视野计相比，Matrix 24-2和原始N-30倍频技术测试的诊断准确性。
Invest Ophthalmol Vis Sci. 2008 Mar;49(3):954-60. doi: 10.1167/iovs.07-0493.
6
Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function.通过评估视网膜神经纤维层厚度和视觉功能来检测早期青光眼。
Invest Ophthalmol Vis Sci. 2001 Aug;42(9):1993-2003.
7
Detection of psychophysical and structural injury in eyes with glaucomatous optic neuropathy and normal standard automated perimetry.青光眼性视神经病变且标准自动视野计检查结果正常的眼睛中精神物理学和结构损伤的检测。
Arch Ophthalmol. 2006 Feb;124(2):169-76. doi: 10.1001/archopht.124.2.169.
8
Can frequency-doubling technology and short-wavelength automated perimetries detect visual field defects before standard automated perimetry in patients with preperimetric glaucoma?倍频技术和短波长自动视野计能否在视野检查前青光眼患者出现标准自动视野计检测到的视野缺损之前检测到视野缺损？
J Glaucoma. 2007 Jun-Jul;16(4):372-83. doi: 10.1097/IJG.0b013e31803bbb17.
9
Visual function-specific perimetry to identify glaucomatous visual loss using three different definitions of visual field abnormality.使用三种不同的视野异常定义，进行视觉功能特异性视野检查以识别青光眼性视力丧失。
Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1234-40. doi: 10.1167/iovs.08-2535. Epub 2008 Oct 31.
10
Identifying glaucomatous vision loss with visual-function-specific perimetry in the diagnostic innovations in glaucoma study.在青光眼研究的诊断创新中，通过具有视觉功能特异性的视野检查来识别青光眼性视力丧失。
Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3381-9. doi: 10.1167/iovs.05-1546.

引用本文的文献

1
Impact of Myopia on the Utility of the Photopic Negative Response Ratio for Glaucoma Assessment.近视对用于青光眼评估的明视负反应率效用的影响。
J Clin Med. 2025 Jan 21;14(3):682. doi: 10.3390/jcm14030682.
2
Hemifield-based analysis of pattern electroretinography in normal subjects and patients with preperimetric glaucoma.视野分析在正常人和青光眼前期患者的图形视网膜电图中的应用。
Sci Rep. 2024 Mar 1;14(1):5116. doi: 10.1038/s41598-024-55601-9.
3
Intereye structure-function relationship using photopic negative response in patients with glaucoma or glaucoma suspect.应用明视负向光反应研究青光眼或疑似青光眼患者的眼内结构与功能关系。
Sci Rep. 2022 Aug 16;12(1):13866. doi: 10.1038/s41598-022-17868-8.
4
Attenuated Amplitude of Pattern Electroretinogram in Glaucoma Patients with Choroidal Parapapillary Microvasculature Dropout.脉络膜视乳头旁微血管缺失的青光眼患者图形视网膜电图振幅降低
J Clin Med. 2022 Apr 28;11(9):2478. doi: 10.3390/jcm11092478.
5
Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma.开角型青光眼中图形视网膜电图N95振幅与光学相干断层扫描血管造影的关系
J Clin Med. 2020 Nov 27;9(12):3854. doi: 10.3390/jcm9123854.
6
RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes.RE-PERG，一种用于近视眼中青光眼诊断的新范式。
Clin Ophthalmol. 2019 Jul 24;13:1315-1322. doi: 10.2147/OPTH.S211337. eCollection 2019.
7
Comparison of pattern electroretinograms of glaucoma patients with parafoveal scotoma versus peripheral nasal step.青光眼患者伴中心凹旁视野缺损与鼻侧周边台阶的图形视网膜电流图比较。
Sci Rep. 2019 Mar 5;9(1):3547. doi: 10.1038/s41598-019-39948-y.
8
RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity.重复图形视网膜电图（RE-PERG），一种用于青光眼电生理诊断的新方法，可能会提高图形视网膜电图（PERG）的特异性。
Clin Ophthalmol. 2017 Jan 23;11:209-218. doi: 10.2147/OPTH.S122706. eCollection 2017.
9
Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia.屈光参差性弱视的稳态图形视网膜电图和频率加倍技术
Clin Ophthalmol. 2016 Oct 19;10:2061-2068. doi: 10.2147/OPTH.S117803. eCollection 2016.
10
Electrophysiology and colour: a comparison of methods to evaluate inner retinal function.电生理学与颜色：评估视网膜内层功能方法的比较
Doc Ophthalmol. 2015 Dec;131(3):159-67. doi: 10.1007/s10633-015-9512-z. Epub 2015 Sep 23.

本文引用的文献

1
Repeatability of pattern electroretinogram measurements using a new paradigm optimized for glaucoma detection.使用针对青光眼检测优化的新范式进行图形视网膜电图测量的可重复性。
J Glaucoma. 2009 Aug;18(6):437-42. doi: 10.1097/IJG.0b013e31818c6f44.
2
Effect of operator and optical defocus on the variability of pattern electroretinogram optimized for glaucoma detection (PERGLA).用于青光眼检测的图形视网膜电图（PERGLA）优化中操作者和光学离焦对变异性的影响。
J Glaucoma. 2010 Feb;19(2):77-82. doi: 10.1097/IJG.0b013e31819f934e.
3
Diagnostic accuracy of pattern electroretinogram optimized for glaucoma detection.优化用于青光眼检测的图形视网膜电图的诊断准确性。
Ophthalmology. 2009 Mar;116(3):437-43. doi: 10.1016/j.ophtha.2008.10.026. Epub 2009 Jan 22.
4
Visual function-specific perimetry to identify glaucomatous visual loss using three different definitions of visual field abnormality.使用三种不同的视野异常定义，进行视觉功能特异性视野检查以识别青光眼性视力丧失。
Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1234-40. doi: 10.1167/iovs.08-2535. Epub 2008 Oct 31.
5
Diagnostic accuracy of the Matrix 24-2 and original N-30 frequency-doubling technology tests compared with standard automated perimetry.与标准自动视野计相比，Matrix 24-2和原始N-30倍频技术测试的诊断准确性。
Invest Ophthalmol Vis Sci. 2008 Mar;49(3):954-60. doi: 10.1167/iovs.07-0493.
6
Reproducibility of pattern electroretinogram in glaucoma patients with a range of severity of disease with the new glaucoma paradigm.新型青光眼模式下不同疾病严重程度青光眼患者图形视网膜电图的可重复性
Ophthalmology. 2008 Jun;115(6):957-63. doi: 10.1016/j.ophtha.2007.08.023. Epub 2007 Nov 5.
7
When is glaucoma really glaucoma?青光眼何时才是真正的青光眼？
Clin Exp Optom. 2007 Sep;90(5):376-85. doi: 10.1111/j.1444-0938.2007.00175.x.
8
A new pattern electroretinogram paradigm evaluated in terms of user friendliness and agreement with perimetry.一种根据用户友好性和与视野检查的一致性进行评估的新型视网膜电图范式。
Ophthalmology. 2007 Apr;114(4):671-9. doi: 10.1016/j.ophtha.2006.07.061.
9
Identifying glaucomatous vision loss with visual-function-specific perimetry in the diagnostic innovations in glaucoma study.在青光眼研究的诊断创新中，通过具有视觉功能特异性的视野检查来识别青光眼性视力丧失。
Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3381-9. doi: 10.1167/iovs.05-1546.
10
The psychophysics of glaucoma: improving the structure/function relationship.青光眼的心理物理学：改善结构/功能关系。
Prog Retin Eye Res. 2006 Jan;25(1):79-97. doi: 10.1016/j.preteyeres.2005.06.001. Epub 2005 Aug 2.