Mikelberg F S, Drance S M, Schulzer M, Yidegiligne H M, Weis M M
Department of Ophthalmology, University of British Columbia, Vancouver.
Ophthalmology. 1989 Sep;96(9):1325-8. doi: 10.1016/s0161-6420(89)32718-7.
Computerized image analysis was used to determine the normal axonal count and axon diameter distribution in 12 normal human eyes. Mean axon count per nerve was 969,279 +/- 239,740 and mean axon diameter was 0.72 +/- 0.07 micron. Multiple linear regression disclosed 4909 axons lost yearly (P = 0.08). Statistical analysis did not show a relationship between axon diameter and age or time to fixation. The inferotemporal sector of the nerve had the highest fiber density (P = 0.02). The superonasal nerve had higher mean diameters (P = 0.02). This study may provide a baseline for future pathologic studies.
利用计算机图像分析确定了12只正常人类眼睛的正常轴突计数和轴突直径分布。每条神经的平均轴突计数为969,279±239,740，平均轴突直径为0.72±0.07微米。多元线性回归显示每年有4909根轴突丢失（P = 0.08）。统计分析未显示轴突直径与年龄或固定时间之间存在关联。神经的颞下象限纤维密度最高（P = 0.02）。鼻上神经的平均直径更大（P = 0.02）。本研究可为未来的病理学研究提供基线。
